Intestinal organoids have been used to model development of the crypt–villus axis and uncover signalling pathways that govern the stem-cell niche and induce differentiation. Two studies now take advantage of intestinal organoids to measure the mechanical forces that drive morphogenesis of the crypt and fate specification of its resident cells.
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Nelson, C.M. The mechanics of crypt morphogenesis. Nat Cell Biol 23, 678–679 (2021). https://doi.org/10.1038/s41556-021-00703-z
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DOI: https://doi.org/10.1038/s41556-021-00703-z
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MorphoSim: an efficient and scalable phase-field framework for accurately simulating multicellular morphologies
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