Tangential expansion of neural stem cells in the mammalian neocortex increases the number of cortical columns. A new study shows that neural stem cells that become detached from the apical surface during division regenerate an apical endfoot to ensure tangential expansion in the early stage but later lose this ability when radial expansion occurs.
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References
Smart, I. H. M., Dehay, C., Giroud, P., Berland, M. & Kennedy, H. Cereb. Cortex 12, 37–53 (2002).
Hansen, D. V., Lui, J. H., Parker, P. R. L. & Kriegstein, A. R. Nature 464, 554–561 (2010).
Fietz, S. A. et al. Nat. Neurosci. 13, 690–699 (2010).
Reillo, I., de Juan Romero, C., García-Cabezas, M. Á. & Borrell, V. Cereb. Cortex 21, 1674–1694 (2011).
Betizeau, M. et al. Neuron 80, 442–457 (2013).
Fujita, I. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0436-9 (2019).
Alexandre, P., Reugels, A. M., Barker, D., Blanc, E. & Clarke, J. D. W. Nat. Neurosci. 13, 673–679 (2010).
Das, R. M. & Storey, K. G. EMBO Rep. 13, 448–454 (2012).
Konno, D. et al. Nat. Cell Biol. 10, 93–101 (2008).
Tavano, S. et al. Neuron 97, 1299–1314.e8 (2018).
Kawaue, T. et al. Nat. Commun. 10, 2780 (2019).
LaMonica, B. E., Lui, J. H., Hansen, D. V. & Kriegstein, A. R. Nat. Commun. 4, 1665 (2013).
Martínez-Martínez, M. Á. et al. Nat. Commun. 7, 11812 (2016).
Marsden, M. & DeSimone, D. W. Development 128, 3635–3647 (2001).
Cappello, S. et al. Neuron 73, 911–924 (2012).
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Tsuboi, M., Gotoh, Y. Endfoot regrowth for neural stem cell renewal. Nat Cell Biol 22, 3–5 (2020). https://doi.org/10.1038/s41556-019-0448-5
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DOI: https://doi.org/10.1038/s41556-019-0448-5