Yap signalling is crucial for intestinal regeneration, but its role is largely dispensable in homeostasis. Two studies now reveal Yap-dependent mechanisms of intestinal regeneration and tissue organization: transient expansion of a rare cell type after damage in vivo and Notch–Dll activation for symmetry breaking in organoid development.
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Li, V.S.W. Yap in regeneration and symmetry breaking. Nat Cell Biol 21, 665–667 (2019). https://doi.org/10.1038/s41556-019-0334-1
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DOI: https://doi.org/10.1038/s41556-019-0334-1