It is commonly accepted that disseminated tumour cells survive cytotoxic chemotherapy because they are not proliferating. A new study now finds that, in contrast to this long-standing concept, both dormant and proliferative cancer cells can be protected from chemotherapy when they reside at the perivascular niche.
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Werner-Klein, M., Klein, C.A. Therapy resistance beyond cellular dormancy. Nat Cell Biol 21, 117–119 (2019). https://doi.org/10.1038/s41556-019-0276-7
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DOI: https://doi.org/10.1038/s41556-019-0276-7
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