Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TISSUES-ON-CHIPS

Modelling microvascular pathology

Nature Biomedical Engineering volume 2, pages 349–350 (2018)Cite this article

Subjects

A physiologically relevant microvasculature-on-a-chip device enables the study of microvascular pathology associated with inflammation and haematological diseases.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Microfluidic models for studying angiogenesis and rheology in the microvasculature.
Fig. 2: A hydrogel-based microvasculature-on-a-chip device that recapitulates physiologically relevant aspects of the microcirculation.

References

  1. Akbari, E., Spychalski, G. & Song, J. Microcirculation 24, e12363 (2017).

    Article  Google Scholar 

  2. Haase, K. & Kamm, R. Regen. Med. 12, 285–302 (2017).

    Article  CAS  Google Scholar 

  3. Shevkoplyas, S. et al. Lab Chip 6, 914–920 (2006).

    Article  CAS  Google Scholar 

  4. Lu, X. et al. Microcirculation 24, e12357 (2017).

    Article  Google Scholar 

  5. Boussommier-Calleja, A. et al. Biomaterials https://doi.org/10.1016/j.biomaterials.2018.03.005 (2018).

  6. Galie, P. A. et al. Proc. Natl Acad. Sci. USA 111, 7968–7973 (2014).

    Article  CAS  Google Scholar 

  7. Phan, D. et al. Lab Chip 17, 511–520 (2017).

    Article  CAS  Google Scholar 

  8. Song, J. & Munn, L. Proc. Natl Acad. Sci. USA 108, 15342–15347 (2011).

    Article  CAS  Google Scholar 

  9. Qiu, Y. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0224-z (2018).

Download references

Author information

Authors and Affiliations

  1. Department of Biomedical Engineering, Tulane University, New Orleans, LA, USA

    Jessica Motherwell

  2. J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA

    Jessica Motherwell & Walter Lee Murfee

Authors
  1. Jessica Motherwell
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Walter Lee Murfee
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Walter Lee Murfee.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Motherwell, J., Murfee, W.L. Modelling microvascular pathology. Nat Biomed Eng 2, 349–350 (2018). https://doi.org/10.1038/s41551-018-0251-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-018-0251-9

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research