Exosomes expressing CD47 and loaded with interfering RNA dodge phagocytosis and accumulate in pancreatic tumours to silence the expression of the oncogene Kras in mice, with remarkable therapeutic efficacy.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Application of lipid nanovesicle drug delivery system in cancer immunotherapy
Journal of Nanobiotechnology Open Access 06 May 2022
-
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking
Experimental & Molecular Medicine Open Access 15 March 2019
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Zeng, L. J. et al. Nanomedicine 10, 463–472 (2014).
Rejiba, S., Wack, S., Aprahamian, M. & Hajri, A. Cancer Sci. 98, 1128–1136 (2007).
Golan, T. et al. Oncotarget 6, 24560–24570 (2015).
van der Meel, R. et al. J. Control. Release 195, 72–85 (2014).
Kamerkar, S. et al. Nature 546, 498–503 (2017).
Vader, P., Mol, E. A., Pasterkamp, G. & Schiffelers, R. M. Adv. Drug Del. Rev. 106, 148–156 (2016).
Lai, C. P. et al. ACS Nano 8, 483–494 (2014).
Wiklander, O. P. et al. J. Extracell. Vesicles 4, 26316 (2015).
Hoshino, A. et al. Nature 527, 329–335 (2015).
Hosotani, R. et al. Pancreas 25, e30–e35 (2002).
Commisso, C. et al. Nature 497, 633–637 (2013).
Landesman, Y. et al. Silence 1, 16 (2010).
Kooijmans, S. A. et al. J. Control. Release 172, 229–238 (2013).
Lener, T. et al. J. Extracell. Vesicles 4, 30087 (2015).
Rodriguez, P. L. et al. Science 339, 971–975 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
R.M.S. is founder and chief scientific officer of Excytex.
Rights and permissions
About this article
Cite this article
Kooijmans, S.A.A., Vader, P. & Schiffelers, R.M. Tumour-bound RNA-laden exosomes. Nat Biomed Eng 1, 634–636 (2017). https://doi.org/10.1038/s41551-017-0119-4
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41551-017-0119-4
This article is cited by
-
Nintedanib-loaded exosomes from adipose-derived stem cells inhibit pulmonary fibrosis induced by bleomycin
Pediatric Research (2024)
-
Application of lipid nanovesicle drug delivery system in cancer immunotherapy
Journal of Nanobiotechnology (2022)
-
Packaging RNA drugs into extracellular vesicles
Nature Biomedical Engineering (2020)
-
Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking
Experimental & Molecular Medicine (2019)