Abstract
The association between ulcerative colitis (UC) and erectile dysfunction (ED) has been previously reported. Numerous previous studies have also reported an association between gastrointestinal symptoms and ED. Constipation and diarrhea are common in patients with UC. However, the specific association between bowel movement frequency and ED remains unclear. The aim of this study is to investigate the association between bowel movement frequency and ED in 164 patients with UC. The definition of ED, moderate to severe ED, and severe ED was the Sexual Health Inventory for Men score <22, <12, and <8, respectively. Bowel movement frequency was divided into three categories: (1) high (More than once a day), (2) normal (once a day, reference), and low (less than one time/day). The definition of constipation was based on the Rome I criteria and/or medication for constipation. The prevalence of constipation and ED was 10.4% and 86.0%, respectively. The rate of high, normal, and low bowel movement frequency was 56.1%, 25.0%, and 18.9%, respectively. High bowel movement frequency was independently and positively associated with ED and moderate to severe ED (ED: adjusted odds ratio [OR] 4.42, 95% confidence interval [CI] 1.35–15.98; moderate to severe: adjusted OR 2.98, 95% CI 1.22–7.61). Low bowel movement frequency was independently and positively associated with moderate to severe ED and severe ED (moderate to severe: adjusted OR 3.96, 95% CI 1.27–13.08; severe: adjusted OR 3.20, 95% CI 1.08–9.86). No association between constipation and ED was found. In conclusion, in Japanese patients with UC, both high and low bowel movement frequency were independently and positively associated with ED.
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The datasets used and/or analyzed in the current study are available from the corresponding author on reasonable request.
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Acknowledgements
The authors would like to thank Kenichiro Mori, Keitarou Kawasaki, Yuji Mizukami, Satoshi Imamine, Masamoto Torisu, Harumi Yano, Makoto Yano, Masato Murakami, Aki Hasebe, Masumi Hino, and Tomo Kogama.
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Conceptualization: Shinya Furukawa, Yoichi Hiasa, Eiji Takeshita, and Yoshio Ikeda. Data curation: Teruki Miyake, Osamu Yoshida, Masakazu Hanayama, Shogo Kitahata, Tomoyuki Ninomiya, Sen Yagi, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Kana Shiraishi, Kazuhiro Tange, Yu Hashimoto, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, and Yoshio Ikeda. Investigation: Kana Shiraishi, Kazuhiro Tange, Yu Hashimoto, Sen Yagi, Shogo Kitahata, Tomoyuki Ninomiya, Masakazu Hanayama, Seiyuu Suzuki, Naozumi Shibata, Hidehiro Murakami, Katsuhisa Ohashi, Hideomi Tomida, Yasunori Yamamoto, Eiji Takeshita, and Yoshio Ikeda. Formal analysis: Shinya Furukawa. Software: Shinya Furukawa. Supervision: Yoichi Hiasa. Writing: Shinya Furukawa, Teruki Miyake, Osamu Yoshida. All authors have contributed significantly. All the authors have approved the manuscript and agree with submission to your esteemed journal.
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All patients in this study were informed about the study by well-trained staff and gave written informed consent. The study protocol was prepared in accordance with the 1964 Declaration of Helsinki and subsequent ethical guidelines and was approved by the Ethics Committee of Ehime University School of Medicine (approval number 1505011). This study is also registered UMIN Clinical Trials Registry (000051334).
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Furukawa, S., Miyake, T., Yoshida, O. et al. Association between bowel movement frequency and erectile dysfunction in patients with ulcerative colitis: a cross-sectional study. Int J Impot Res (2024). https://doi.org/10.1038/s41443-024-00884-9
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DOI: https://doi.org/10.1038/s41443-024-00884-9