Abstract
Obesity and arterial stiffness are important risk factors for disease development. However, the relationship between obesity and arterial stiffness remains unclear. We examined the relationship of visceral fat area (VFA) and anthropometric obesity indices with arterial stiffness. This cross-sectional study was conducted among 2 789 participants (50% women) who underwent both VFA and brachial-ankle pulse wave velocity (baPWV) measurements during health checkups. Body mass index (BMI), waist circumference (WC), waist-height ratio (WHtR), a body shape index (ABSI), and body roundness index (BRI) were assessed. Visceral fat area was quantified using abdominal computed tomography. In women, VFA and all anthropometric indices positively correlated with age. In men, VFA, WHtR, ABSI, and BRI positively correlated with age; BMI inversely correlated with age; and WC did not correlate with age. Visceral fat area significantly correlated with anthropometric indices, but its correlation with ABSI was modest. In women, baPWV showed modest correlations with VFA and anthropometric indices and little correlations with BMI. In men, baPWV modestly correlated with VFA, WHtR, ABSI, and BRI, but inversely correlated with BMI and did not significantly correlate with WC. The multivariable-adjusted model showed that VFA and anthropometric indices, except ABSI, were inversely associated with baPWV; however, they were positively associated with metabolic syndrome components, including hypertension, dyslipidemia, and hyperglycemia. A body-shaped index weakly associated positively with baPWV, but misclassified individuals at risk for metabolic syndrome components. Visceral fat area and most anthropometric obesity indices were positively associated with hypertension, dyslipidemia, and hyperglycemia, but inversely associated with baPWV.
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References
Ben-Shlomo Y, Spears M, Boustred C, May M, Anderson SG, Benjamin EJ, et al. Aortic pulse wave velocity improves cardiovascular event prediction: an individual participant meta-analysis of prospective observational data from 17,635 subjects. J Am Coll Cardiol. 2014;63:636–46.
Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: A systematic review and meta-analysis. J Am Coll Cardiol. 2010;55:1318–27.
Vlachopoulos C, Aznaouridis K, Terentes-Printzios D, Ioakeimidis N, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with brachial-Ankle elasticity index: A systematic review and meta-analysis. Hypertension. 2012;60:556–62.
Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, et al. Brachial-ankle pulse wave velocity and the risk prediction of cardiovascular disease novelty and significance. Hypertension. 2017;69:1045–52.
Chirinos JA, Segers P, Hughes T, Townsend R. Large-Artery stiffness in health and disease: JACC State-of-the-Art Review. J Am Coll Cardiol. 2019;74:1237–63.
Powell-Wiley TM, Poirier P, Burke LE, Després J-P, Gordon-Larsen P, Lavie CJ, et al. Obesity and cardiovascular disease: A scientific statement from the American Heart Association. Circulation. 2021;143:e984–e1010.
Kim H-L, Ahn D-W, Kim SH, Lee DS, Yoon SH, Zo J-H, et al. Association between body fat parameters and arterial stiffness. Sci Rep. 2021;11:20536.
Li G, Yao T, Wu X-W, Cao Z, Tu Y-C, Ma Y, et al. Novel and traditional anthropometric indices for identifying arterial stiffness in overweight and obese adults. Clin Nutr. 2020;39:893–900.
Wohlfahrt P, Somers VK, Cifkova R, Filipovsky J, Seidlerova J, Krajcoviechova A, et al. Relationship between measures of central and general adiposity with aortic stiffness in the general population. Atherosclerosis. 2015;235:625–31.
Haraguchi N, Koyama T, Kuriyama N, Ozaki E, Matsui D, Watanabe I, et al. Assessment of anthropometric indices other than BMI to evaluate arterial stiffness. Hypertens Res. 2019;42:1599–605.
Sugiura T, Dohi Y, Takagi Y, Yoshikane N, Ito M, Suzuki K, et al. Relationships of obesity-related indices and metabolic syndrome with subclinical atherosclerosis in middle-aged untreated Japanese workers. J Atheroscler Thromb. 2020;27:342–52.
Gomez-Sanchez L, Garcia-Ortiz L, Patino-Alonso MC, Recio-Rodriguez JI, Rigo F, Martí R, et al. Adiposity measures and arterial stiffness in primary care: The MARK prospective observational study. BMJ Open. 2017;7:e016422.
Rodrigues SL, Baldo MP, Lani L, Nogueira L, Mill JG, Sa Cunha RD. Body mass index is not independently associated with increased aortic stiffness in a Brazilian population. Am J Hypertens. 2012;25:1064–9.
Logan JG, Kang H, Kim S, Duprez D, Kwon Y, Jacobs DR Jr, et al. Association of obesity with arterial stiffness: The multi-ethnic study of atherosclerosis (MESA). Vasc Med. 2020;25:309–18.
Won K-B, Chang H-J, Niinuma H, Niwa K, Jeon K, Cho I-J, et al. Inverse association between central obesity and arterial stiffness in Korean subjects with metabolic syndrome: a cross-sectional cohort study. Diabetol Metab Syndr. 2015;7:3.
Zachariah JP, Rong J, Larson MG, Hamburg NM, Benjamin EJ, Vasan RS, et al. Metabolic predictors of change in vascular function. Hypertension. 2018;71:237–42.
Kim H-L, Lim W-H, Seo J-B, Kim S-H, Zo J-H, Kim M-A. Association between body mass index and arterial stiffness. Cardiometab Syndr J. 2022;2:49.
Zuo J, Tang B, O’Rourke MF, Avolio AP, Adji A. Association between brachial-ankle pulse wave velocity as a marker of arterial stiffness and body mass index in a Chinese population. J Cardiovasc Dev Dis. 2022;9:75 https://doi.org/10.3390/jcdd9030075
Rao G, Powell-Wiley TM, Ancheta I, Hairston K, Kirley K, Lear SA, et al. Identification of obesity and cardiovascular risk in ethnically and racially diverse populations. Circulation. 2015;132:457–72.
Krakauer NY, Krakauer JC. A new body shape index predicts mortality hazard independently of body mass index. PLoS One. 2012;7:e39504.
Thomas DM, Bredlau C, Bosy-Westphal A, Mueller M, Shen W, Gallagher D, et al. Relationships between body roundness with body fat and visceral adipose tissue emerging from a new geometrical model. Obesity. 2013;21:2264–71.
Bouchi R, Asakawa M, Ohara N, Nakano Y, Takeuchi T, Murakami M, et al. Indirect measure of visceral adiposity “A body shape index” (ABSI) is associated with arterial stiffness in patients with type 2 diabetes. BMJ Open Diabetes Res Care. 2016;4:e000188.
Sugiura T, Dohi Y, Takagi Y, Yokochi T, Yoshikane N, Suzuki K, et al. A body shape index could serve to identify individuals with metabolic syndrome and increased arterial stiffness in the middle-aged population. Clin Nutr ESPEN. 2021;46:251–8.
Choi HS, Cho YH, Lee SY, Park EJ, Kim YJ, Lee JG, et al. Association between new anthropometric parameters and arterial stiffness based on brachial-ankle pulse wave velocity. Diabetes Metab Syndr Obes. 2019;12:1727–33.
von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61:344–9.
[Definition and the diagnostic standard for metabolic syndrome--committee to evaluate diagnostic standards for metabolic syndrome]. Nihon Naika Gakkai Zasshi 2005; 94: 794–809.
Ishida A, Miyagi M, Kinjo K, Ohya Y. Age- and sex-related effects on ankle-brachial index in a screened cohort of Japanese: The Okinawa peripheral arterial disease study (OPADS). Eur J Prev Cardiol. 2014;21:712–8.
Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis. 2009;53:982–92.
Zamboni M, Mazzali G, Fantin F, Rossi A, Di Francesco V. Sarcopenic obesity: A' new category of obesity in the elderly. Nutr Metab Cardiovasc Dis. 2008;18:388–95.
Fujita M, Sato Y, Nagashima K, Takahashi S, Hata A. Predictive power of a body shape index for development of diabetes, hypertension, and dyslipidemia in Japanese adults: a retrospective cohort study. PLoS One. 2015;10:e0128972.
Cheung YB. “A body shape index” in middle-age and older Indonesian population: scaling exponents and association with incident hypertension. PLoS One. 2014;9:e85421.
Matsuzawa Y, Nakamura T, Takahashi M, Ryo M, Inoue S, Ikeda Y, et al. New criteria for “obesity disease” in Japan. Circ J. 2002;66:987–92.
Asia Pacific Cohort Studies Collaboration. The burden of overweight and obesity in the Asia-Pacific region. Obes Rev. 2007;8:191–6.
Chau K, Girerd N, Bozec E, Ferreira JP, Duarte K, Nazare JA, et al. Association between abdominal adiposity and 20-year subsequent aortic stiffness in an initially healthy population-based cohort. J Hypertens. 2018;36:2077–84.
Shirai K, Utino J, Otsuka K, Takata M. A novel blood pressure-independent arterial wall stiffness parameter; cardio-ankle vascular index (CAVI). J Atheroscler Thromb. 2006;13:101–7.
Topouchian J, Labat C, Gautier S, Bäck M, Achimastos A, Blacher J, et al. Effects of metabolic syndrome on arterial function in different age groups: the advanced approach to arterial stiffness study. J Hypertens. 2018;36:824–33.
Agbaje AO, Barker AR, Tuomainen T-P. Cumulative muscle mass and blood pressure but not fat mass drives arterial stiffness and carotid intima-media thickness progression in the young population and is unrelated to vascular organ damage. Hypertens Res. 2023;46:984–99.
Bell JA, Carslake D, O’Keeffe LM, Frysz M, Howe LD, Hamer M, et al. Associations of body mass and fat indexes with cardiometabolic traits. J Am Coll Cardiol. 2018;72:3142–54.
González-Muniesa P, Mártinez-González M-A, Hu FB, Després J-P, Matsuzawa Y, Loos RJF, et al. Obesity. Nat Rev Dis Prim. 2017;3:17034.
Ndumele CE, Matsushita K, Lazo M, Bello N, Blumenthal RS, Gerstenblith G, et al. Obesity and subtypes of incident cardiovascular disease. J Am Heart Assoc. 2016;5:e003921 https://doi.org/10.1161/JAHA.116.003921
Acknowledgements
We are grateful to all the participants of the study and staff of the Okinawa Health Promotion Foundation. We would like to thank Editage (www.editage.com) for English language editing.
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AI contributed to the conception and design of the study. TS contributed to data acquisition and analysis. AI and HT contributed to data analysis and interpretation. AI and HT drafted the manuscript. All authors have read and approved the final version of the manuscript.
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Ishida, A., Taira, H., Shinzato, T. et al. Association between visceral fat mass and arterial stiffness among community-based screening participants. Hypertens Res 46, 2488–2496 (2023). https://doi.org/10.1038/s41440-023-01350-7
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DOI: https://doi.org/10.1038/s41440-023-01350-7
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