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Very short-term beat-by-beat blood pressure variability in the supine position at rest correlates well with the nocturnal blood pressure variability assessed by ambulatory blood pressure monitoring

Hypertension Research volume 45, pages 1008–1017 (2022)Cite this article

Abstract

Blood pressure variability (BPV) is an important indicator in risk stratification for hypertension. Among the daily BPVs assessed using a 24-h ambulatory blood pressure (BP) monitor nocturnal systolic BPV has been suggested to predict cardiovascular risks. We hypothesized that very short-term BPV at rest would correlate with nocturnal BPV because of the shared autonomic BP regulatory system under no daily exertion. Thirty untreated normotensive and hypertensive adults underwent 30-min continuous beat-by-beat BP recordings in the supine position, followed by 24-h ambulatory blood pressure monitoring (ABPM). The relationship between very short-term BPV (standard deviation (SD), coefficient of variation (CV)) and daytime and nocturnal BPV (SD, CV, average real variability (ARV), and standardized ARV (CV-ARV)) was assessed with Pearson’s correlation coefficients. Very short-term BPV correlated significantly with nocturnal BPV (ARV, r = 0.604, p < 0.001) but not with daytime BPV. These trends were more pronounced with the increasing data length of continuous beat-by-beat BP recording. Using a data segment from the last 10 min of a 30-min continuous beat-by-beat BP recording resulted in a stronger correlation between very short-term BPV and nocturnal BPV than using earlier segments. The findings of this study suggest that very short-term BPV in the supine position at rest may predict nocturnal BPV. Since the burden of ABPM for patients has hindered clinical dissemination, very short-term BPV has the potential to develop a novel index of BPV.

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Acknowledgements

This work was supported by a Medical-Engineering Collaboration project and research and development of supportive device technology for medicine using ICT from the Japan Agency for Medical Research and Development (18he1102003h0004, 20he1302033j0002), the Japan Foundation for Applied Enzymology. (VBIC: Vascular Biology of Innovation), the Intramural Research Fund for Cardiovascular Diseases of National Cerebral and Cardiovascular Center (31-6-4, 21-2-9) and a research grant from Omron Healthcare Co., Ltd.

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Authors and Affiliations

  1. Graduate School of Information Science, Nara Institute of Science and Technology, Ikoma, Japan

    Hiroyuki Kinoshita & Shigehiko Kanaya

  2. Technology Development HQ, Omron Healthcare Co., Ltd., Muko, Japan

    Hiroyuki Kinoshita & Jumpei Mano

  3. Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan

    Keita Saku

  4. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Hiroshi Mannoji

  5. Circulatory System Research Foundation, Fukuoka, Japan

    Kenji Sunagawa

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Correspondence to Keita Saku.

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Conflict of interest

Hiroyuki Kinoshita and Jumpei Mano are employees of Omron Healthcare Co., Ltd. Kenji Sunagawa worked at the Department of Therapeutic Regulation of Cardiovascular Homeostasis, Center for Disruptive Cardiovascular Medicine, Kyushu University, which was endowed by Omron Healthcare Co., Ltd., and works at the Circulatory System Research Foundation, which is endowed by Omron Healthcare Co., Ltd. Kenji Sunagawa also serves as a consultant of Omron Healthcare Co., Ltd. Keita Saku worked at the Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, which was endowed by Omron Healthcare Co., Ltd., and receives a research grant from Omron Healthcare Co., Ltd. Hiroshi Mannoji and Shigehiko Kanaya declare no conflicts of interest.

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Kinoshita, H., Saku, K., Mano, J. et al. Very short-term beat-by-beat blood pressure variability in the supine position at rest correlates well with the nocturnal blood pressure variability assessed by ambulatory blood pressure monitoring. Hypertens Res 45, 1008–1017 (2022). https://doi.org/10.1038/s41440-022-00911-6

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