Abstract
IgA Nephropathy (IgAN) is one of the most common causes of chronic kidney damage worldwide. Identifying new genetic factors associated with IgAN risk is of invaluable importance. To explore the association between polymorphisms of IL-23R and IL-17A and the susceptibility of IgAN, 164 IgAN patients and 192 healthy controls were genotyped for five SNPs in a Chinese Han population. A comparative analysis between genotype distributions, clinical indexes and pathological grades in the IgAN patients was also performed. The GG genotype and a G allele of rs7517847 were associated with a decreased IgAN risk (OR: 0.545; 95% CI: 0.299–0.993; p = 0.046; OR: 0.730; 95% CI: 0.541–0.984; p = 0.039) compared to the TT genotype and T allele respectively. Furthermore, the AA genotype of rs2275913 appeared to reduce the IgAN risk (OR: 0.405; 95% CI: 0.209–0.786; p = 0.007) compared to the GG genotype. Consistently, individuals harboring an AA genotype had a lower IgAN risk (OR: 0.380; 95% CI: 0.211–0.686; p = 0.001) under the recessive model. Our study demonstrated for the first time the significant associations of rs7517847 in IL-23R and rs2275913 in IL-17A with the risk of IgAN in Chinese Han.
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Acknowledgements
We thank Ruyu Ren and Mengyuan Lyu for assistance in statistical analysis.
Funding
This work was sponsored by the National Natural Science Foundation of China [81902129] and Science and Technology Agency of Sichuan Province [2019YFS0313 and 2019YFS0321].
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HL, ZH, JZ, and BY designed the study; ZH and JZ were responsible for recruitment of subjects; HL, ZH, and JZ performed experiments and conducted data management; HL and BY performed statistical analyses and interpreted results; HL wrote the manuscript. All authors revised the manuscript.
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Liao, H., Huang, Z., Zhang, J. et al. Association of genetic polymorphisms in IL-23R and IL-17A with the susceptibility to IgA nephropathy in a Chinese Han population. Genes Immun 23, 33–41 (2022). https://doi.org/10.1038/s41435-021-00160-6
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DOI: https://doi.org/10.1038/s41435-021-00160-6