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Roseburia, a decreased bacterial taxon in the gut microbiota of patients suffering from anorexia nervosa

European Journal of Clinical Nutrition volume 76, pages 1486–1489 (2022)Cite this article

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Abstract

Anorexia nervosa (AN) is a severe eating disorder which can lead to malnutrition and life threatening complications with high mortality rates. We designed our analysis to identify gut microbial taxa differentially abundant between AN and HC across different 16S rRNA gene datasets. We identified a reduced abundance, diversity and richness of Roseburia genus in the microbiota of patients with AN. Cares leading to partial recovery of patients with AN during hospitalization did not restore Roseburia to the levels of HC. AN dietary habit, either purgative or restrictive, did not affect Roseburia abundance. Roseburia genus and related species abundance were correlated with different health host metabolic markers. Roseburia species are key functional taxa in the human gut microbiome. Low gut Roseburia levels have been linked with other human pathologies. Our study highlights Roseburia species as a major decreased component in the gut of patients with AN.

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Fig. 1: Roseburia, a decreased bacterial taxon in AN gut microbiota.

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Data availability

Datasets for this research are available under NCBI project number PRJEB11199 and PRJNA375065 for Mack et al. and Borgo et al. respectively. Datasets Hanachi et al are available under request to MH.

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Acknowledgements

We are grateful to the INRAE MIGALE bioinformatics facility (MIGALE, INRAE, 2020. Migale Bioinformatics Facility, https://doi.org/10.15454/1.5572390655343293E12) for providing help, computing and storage resources.

Funding

This project was funded by the European Commission under ERC-2017-AdG n. 788191 - Homo.symbiosus and by the French Foundation under project number 00101804.

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Author notes

  1. Hervé M. Blottière

    Present address: University of Nantes, INRAE, UMR 1280 PhAN, Nantes, France

Authors and Affiliations

  1. Paris-Saclay university, INRAE, AgroParisTech, Micalis Institute, Jouy-en-Josas, France

    Stanislas Mondot, Joël Doré, Hervé M. Blottière & Mouna Hanachi

  2. Nutrition Unit, Paul Brousse University Hospital, Villejuif; Assistance Publique–Hôpitaux de Paris, Paris, France

    Laurine Lachkar & Mouna Hanachi

  3. University of Paris, Paris, France

    Laurine Lachkar

  4. Paris-Saclay university, MetaGenoPolis, Jouy en Josas, France

    Joël Doré & Hervé M. Blottière

  5. Paris-Saclay university, Le Kremlin-Bicêtre, France

    Mouna Hanachi

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  1. Stanislas Mondot
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  2. Laurine Lachkar
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  4. Hervé M. Blottière
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  5. Mouna Hanachi
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Contributions

SM conceived the study design, collected the data, performed the statistical analysis and wrote the manuscript. All authors edited, reviewed and approved the final manuscript.

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Correspondence to Stanislas Mondot or Mouna Hanachi.

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Mondot, S., Lachkar, L., Doré, J. et al. Roseburia, a decreased bacterial taxon in the gut microbiota of patients suffering from anorexia nervosa. Eur J Clin Nutr 76, 1486–1489 (2022). https://doi.org/10.1038/s41430-022-01116-3

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