Abstract
Plazomicin is a new aminoglycoside with broad-spectrum activity against multidrug-resistant strains. The aim of this study was to assess the susceptibility of the K. pneumoniae strains to plazomicin and other aminoglycosides. The activity of plazomicin in combination with ceftazidim-avibactam or meropenem with selected strains was evaluated. The study involved 60 ESβL-positive K. pneumoniae isolates and 50 carbapenemase-positive. The susceptibility to aminoglycosides was tested using the gradient strip. The in vitro activities of plazomicin and ceftazidim-avibactam or meropenem were evaluated using the MTSTM cross synergy method. Plazomicin exhibited high activity against K. pneumoniae with MICs ranging from 0.19 to 4 µg ml−1 for ESβL-positive strains and from 0.25 to 256 µg ml−1 for carbapenemase-positive strains. No antagonism was identified with any combinations. Plazomicin demonstrated excellent in vitro activity against analyzed strains, suggesting that this antibiotic may be an effective therapeutic option in the treatment of infections caused by MDR K. pneumoniae strains.
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References
Krause KM, Serio AW, Kane TR, Connolly LE. Aminoglycosides: An Overview. Cold Spring Harb Perspect Med. 2016;6:a027029.
Alfieri A, Di Franco S, Donatiello V, Maffei V, Fittipaldi C, Fiore M, et al. Plazomicin against Multidrug-Resistant Bacteria: A Scoping Review. Life. 2022;12:1949.
Serio AW, Keepers T, Krause KM. Plazomicin Is Active Against Metallo-β-Lactamase-Producing Enterobacteriaceae. Open Forum Infect Dis. 2019;6:ofz123.
Blanchard LS, Van Belkum A, Dechaume D, Armstrong TP, Emery CL, Ying YX, et al. Multicenter Clinical Evaluation of ETEST Plazomicin (PLZ) for Susceptibility Testing of Enterobacterales. Ledeboer NA. J Clin Microbiol. 2022;60:e01831–21.
EUCAST Clinical breakpoints and dosing of antibiotics. 2023. Available at: https://www.eucast.org/clinical_breakpoints. Assessed 3 October 2023.
Clark JA, Burgess DS. Plazomicin: a New Aminoglycoside in the Fight Against Antimicrobial Resistance. Ther Adv Infect Dis. 2020;7:2049936120952604.
Wareham DW, Bean DC. In Vitro Activities of Polymyxin B, Imipenem, and Rifampin against Multidrug-Resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2006;50:825–6.
Data from the ECDC Surveillance Atlas - Antimicrobial Resistance. 2017. Available at: https://www.ecdc.europa.eu/en/antimicrobial-resistance/surveillance-and-disease-data/data-ecdc.
Castanheira M, Duncan LR, Mendes RE, Sader HS, Shortridge D. Activity of Ceftolozane-Tazobactam against Pseudomonas aeruginosa and Enterobacteriaceae Isolates Collected from Respiratory Tract Specimens of Hospitalized Patients in the United States during 2013 to 2015. Antimicrob Agents Chemother. 2018;62:e02125–17.
Castanheira M, Sader HS, Mendes RE, Jones RN. Activity of Plazomicin Tested against Enterobacterales Isolates Collected from U.S. Hospitals in 2016-2017: Effect of Different Breakpoint Criteria on Susceptibility Rates among Aminoglycosides. Antimicrob Agents Chemother. 2020;64:e02418–19.
Castanheira M, Deshpande LM, Woosley LN, Serio AW, Krause KM, Flamm RK. Activity of Plazomicin Compared with Other Aminoglycosides against Isolates from European and Adjacent Countries, including Enterobacteriaceae Molecularly Characterized for Aminoglycoside-Modifying Enzymes and other Resistance Mechanisms. J Antimicrob Chemother. 2018;73:3346–54.
Saravolatz LD, Stein GE. Plazomicin: A New Aminoglycoside. Clin Infect Dis. 2020;70:704–9.
Zhang Y, Kashikar A, Bush K. In Vitro Activity of Plazomicin against β-Lactamase-Producing Carbapenem-Resistant Enterobacteriaceae (CRE). J Antimicrob Chemother. 2017;72:2792–5.
Galani I, Papoutsaki V, Karantani I, Karaiskos I, Galani L, Adamou P, et al. In Vitro Activity of Ceftolozane/Tazobactam Alone and in Combination with Amikacin against MDR/XDR Pseudomonas aeruginosa isolates from Greece. J Antimicrob Chemother. 2020;75:2164–72.
Jacobs MR, Good CE, Hujer AM, Abdelhamed AM, Rhoads DD, Hujer KM, et al. ARGONAUT II Study of the In Vitro Activity of Plazomicin against Carbapenemase-Producing Klebsiella pneumoniae. Antimicrob Agents Chemother. 2020;64:e00012–20.
Fleischmann WA, Greenwood-Quaintance KE, Patel R. In Vitro Activity of Plazomicin Compared to Amikacin, Gentamicin, and Tobramycin against Multidrug-Resistant Aerobic Gram-Negative Bacilli. Antimicrob Agents Chemother. 2020;64:e01711–19.
Martins AF, Bail L, Ito CAS, da Silva Nogueira K, Dalmolin TV, Martins AS, et al. Antimicrobial Activity of Plazomicin against Enterobacteriaceae-Producing Carbapenemases from 50 Brazilian Medical Centers. Diagn Microbiol Infect Dis. 2018;90:228–32.
Thwaites M, Hall D, Stoneburner A, Shinabarger D, Serio AW, Krause KM, et al. Activity of Plazomicin in Combination with other Antibiotics against Multidrug-Resistant Enterobacteriaceae. Diagn Microbiol Infect Dis. 2018;92:338–45.
Rodríguez-Avial I, Pena I, Picazo JJ, Rodríguez-Avial C, Culebras E. In vitro Activity of the Next-Generation Aminoglycoside Plazomicin Alone and in Combination with Colistin, Meropenem, Fosfomycin or Tigecycline against Carbapenemase-Producing Enterobacteriaceae Strains. Int J Antimicrob Agents. 2015;46:616–21.
Acknowledgements
This research was financially supported by Nicolaus Copernicus University funds for the basic research activity of the Microbiology Department Ludwik Rydygier Collegium Medicum in Bydgoszcz, Poland.
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Sękowska, A. In vitro activity of plazomicin and other aminoglycosides against Klebsiella pneumoniae multidrug-resistant strains. J Antibiot 77, 548–551 (2024). https://doi.org/10.1038/s41429-024-00734-2
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DOI: https://doi.org/10.1038/s41429-024-00734-2