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Characteristics and outcome of synchronous bilateral Wilms tumour in the SIOP WT 2001 Study: Report from the SIOP Renal Tumour Study Group (SIOP-RTSG)

British Journal of Cancer volume 131, pages 972–981 (2024)Cite this article

Subjects

Abstract

Background

Among patients with nephroblastoma, those with bilateral disease are a unique population where maximising tumour control must be balanced with preserving renal parenchyma.

Methods

The SIOP 2001 protocol recommended surgery after neoadjuvant cycle(s) of Dactinomycin and Vincristine (AV) with response-adapted intensification, if needed. Adjuvant treatment was given based on the lesion with the worst histology.

Results

Three hundred and twenty seven patients with stage V disease were evaluable: 174 had bilateral Wilms tumour (BWT), 101 unilateral WT and contralateral nephroblastomatosis (NB) and 52 bilateral nephroblastomatosis. In these three groups, the estimated 5y-EFS was 76.1%, 84.6%, and 74.9%, respectively. AV chemotherapy alone was the successful chemotherapy for 58.7% of all the patients and 65.6% of the non-metastatic patients. Among the 174 patients with BWT, 149 (88.2%) had at least one nephron-sparing surgery. Twenty of 61 bilateral stage I patients were treated with four-week AV postoperatively achieving 94.4% 5y-EFS. At last follow-up, 87% of patients had normal renal function.

Conclusions

This study demonstrates that AV without anthracyclines is sufficient to achieve NSS and good survival in the majority of patients. For patients with bilateral stage I WT and intermediate risk histology, only four weeks adjuvant AV seems to be sufficient.

Clinical Trial Registration

NCT00047138

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Fig. 1: Preoperative treatment.
Fig. 2: Event-free survival in the 44 patients with stage I, IR tumours on both sides according to the adjuvant treatment: AV1/ AV2/AVD.
Fig. 3: EFS and OS for the three groups.
Fig. 4: Overall survival by time to surgery (BWT- Bilateral Wilms Tumour- only).
Fig. 5: EFS and OS according to the chemotherapy strategy (AV only versus others).

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Data availability

All data generated or analysed during this study are included in this published article [and its supplementary information files].

References

  1. Breslow N, Olshan A, Beckwith JB, Green DM. Epidemiology of Wilms tumour. Med Pediatr Oncol. 1993;21:172–81.

    Article  CAS  PubMed  Google Scholar 

  2. Charlton J, Irtan S, Bergeron C, Pritchard-Jones K. Bilateral Wilms tumour: a review of clinical and molecular features. Expert Rev Mol Med. 2017;19:e8.

    Article  PubMed  PubMed Central  Google Scholar 

  3. Coppes MJ, de Kraker J, van Dijken PJ, Perry HJ, Delemarre JF, Tournade MF, et al. Bilateral Wilms’ Tumour: long-term survival and some epidemiological features. J Clin Oncol. 1989;7:310–5.

    Article  CAS  PubMed  Google Scholar 

  4. Tournade MF, Com-Nougué C, De Kraker J, Ludwig R, Rey A, Burgers JMB, et al. Optimal duration of preoperative therapy in unilateral and nonmetastatic Wilms’ Tumour in children older than 6 months: Results of the Ninth International Society of Pediatric Oncology Wilms’ Tumour Trial and Study. J Clin Oncol. 2001;19:488–500.

    Article  CAS  PubMed  Google Scholar 

  5. Furtwängler R, Schmolze M, Graber S, Leuschner I, Amann G, Schenk JP, et al. Pretreatment for bilateral Nephroblastomatosis is an Independent risk factor for progressive disease in patients with Stage V Nephroblastoma. Klin Padiatr. 2014;226:175–81.

    Article  PubMed  Google Scholar 

  6. Sudour H, Audry G, Schleimacher G, Patte C, Dussart S, Bergeron C. Bilateral Wilms Tumours (WT) treated with the SIOP 93 protocol in France: epidemiological survey and patient outcome. Pediatr Blood Cancer. 2012;59:57–61.

    Article  PubMed  Google Scholar 

  7. Ehrlich P, Chi YY, Chintagumpala MM, Hoffer FA, Perlman EJ, Kalapurakal JA, et al. Results of the first prospective Multi-institutional Treatment Study in Children With Bilateral Wilms Tumour (AREN0534): A report from the Children’s Oncology Group. Ann Surg. 2017;266:470–8.

    Article  PubMed  Google Scholar 

  8. Indolfi P, Jenkner A, Terenziani M, Crocoli A, Serra A, Collini P, et al. Synchronous bilateral Wilms Tumour: a report from the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP). Cancer. 2013;119:1586–92.

    Article  CAS  PubMed  Google Scholar 

  9. Wilde JC, Aronson DC, Sznajder B, Van Tinteren H, Powis M, Okoye B, et al. Nephron sparing surgery (NSS) for unilateral wilms Tumour (UWT): the SIOP 2001 experience. Pediatr Blood Cancer. 2014;61:2175–9.

    Article  PubMed  Google Scholar 

  10. Welter N, Wagner A, Furtwangler R, Melchior P, Kager L, Vokuhl C, et al. Characteristics of Nephroblastoma/Nephroblastomatosis in children with a clinically reported underlying malformation or cancer predisposition syndrome. Cancers. 2021;13:5016.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kubiak R, Gundeti M, Duffy PG, Ransley PG, Wilcox DT. Renal function and outcome following salvage surgery for bilateral Wilms’ Tumour. J Pediatr Surg. 2004;39:1667–72.

    Article  PubMed  Google Scholar 

  12. Murphy AJ, Davidoff AM. Bilateral Wilms tumour: A surgical perspective. Children. 2018;5:134.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Pritchard-Jones K, Bergeron C, de Camargo B, van den Heuvel-Eibrink MM, Acha T, Godzinski J, et al. Omission of doxorubicin from the treatment of stage II-III, intermediate-risk Wilms’ tumour (SIOP WT 2001): an open-label, non-inferiority, randomised controlled trial. Lancet. 2015;386:1156–64.

    Article  CAS  PubMed  Google Scholar 

  14. Van Den Heuvel-Eibrink MM, Van Tinteren H, Bergeron C, Coulomb-L’Hermine A, De Camargo B, Leuschner I, et al. Outcome of localised blastemal-type Wilms tumour patients treated according to intensified treatment in the SIOP WT 2001 protocol, a report of the SIOP Renal Tumour Study Group (SIOP-RTSG). Eur J Cancer. 2015;51:498–506.

    Article  PubMed  Google Scholar 

  15. Furtwängler R, Gooskens SL, van Tinteren H, de Kraker J, Schleiermacher G, Bergeron C, et al. Clear cell sarcomas of the kidney registered on International Society of Pediatric Oncology (SIOP) 93-01 and SIOP 2001 protocols: a report of the SIOP Renal Tumour Study Group. Eur J Cancer. 2013;49:3497–506.

    Article  PubMed  Google Scholar 

  16. Hamilton TE, Ritchey ML, Haase GM, Argani P, Peterson SM, Anderson JR, et al. The management of synchronous bilateral wilms Tumour: A report from the National Wilms Tumour Study Group. Ann Surg. 2011;253:1004–10.

    Article  PubMed  Google Scholar 

  17. Rapley EA, Barfoot R, Bonaïti-Pellié C, Chompret A, Foulkes W, Perusinghe N, et al. Evidence for susceptibility genes to familial Wilms tumour in addition to WT1, FWT1 and FWT2. BJC. 2000;82:177–83.

    Article  Google Scholar 

  18. Ehrlich PF. Bilateral Wilms’ Tumour: the need to improve outcomes. Expert Rev Anticancer Ther. 2009;9:963–73.

    Article  PubMed  Google Scholar 

  19. Weirich A, Ludwig R, Graf N, Abel U, Leuschner I, Vujanic GM, et al. Survival in nephroblastoma treated according to the trial and study SIOP-9/GPOH with respect to relapse and morbidity. Ann Oncol. 2004;15:808.

    Article  CAS  PubMed  Google Scholar 

  20. Perlman EJ, Faria P, Soares A, Hoffer F, Sredni S, Ritchey M, et al. Hyperplastic perilobar nephroblastomatosis: Long-term survival of 52 patients. Pediatr Blood Cancer. 2006;46:203–21.

    Article  PubMed  Google Scholar 

  21. Shamberger RC, Haase GM, Argani P, Perlman EJ, Cotton CA, Takashima J, et al. Bilateral Wilms’ Tumours with progressive or nonresponsive disease. J Pediatr Surg. 2006;41:652–7.

    Article  PubMed  Google Scholar 

  22. Verschuur AC, Vujanic GM, Van Tinteren H, Jones KP, de Kraker J, Sandstedt B. Stromal and epithelial predominant Wilms tumours have an excellent outcome: the SIOP 93 01 experience. Pediatr Blood cancer. 2010;55:233–8.

    Article  PubMed  Google Scholar 

  23. Vujanic GM, Gessler M, Ooms A, Collini P, Coulomb-l’Hermine A, D’Hooghe E, et al. The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol. Nat Rev Urol. 2018;15:693–701.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Treger TD, Chagtai T, Butcher R, Cresswell GD, Al-Saadi R, Brok J, et al. Somatic TP53 mutations are detectable in circulating tumour DNA from children with anaplastic Wilms tumours. Transl Oncol. 2018;11:1301–6.

    Article  PubMed  PubMed Central  Google Scholar 

  25. Littooij AS, Nikkels PG, Hulsbergen-van de Kaa CA, van de Ven CP, van den Heuvel-Eibrink MM, Olsen ØE. Apparent diffusion coefficient as it relates to histopathology finding in post chemotherapy nephroblastoma: a feasibility study. Pediatr Radiol. 2017;47:1608–14.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Van den Heuvel-Eibrink MM, Hol JA, Pritchard-Jones K, van Tinteren H, Furtwangler R, Verschuur AC, et al. Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol. Nat Rev Urol. 2017;14:743–52.

    Article  PubMed  Google Scholar 

  27. Fialkowski E, Sudour-Bonnange H, Vujanic GM, Shamberger RC, Chowdhury T, Aldrink JH, et al. The varied spectrum of nephroblastomatosis, nephrogenic rests, and Wilms Tumours: Review of current definitions and challenges of the field. Pediatr Blood Cancer. 2023;70:e30162.

    Article  PubMed  Google Scholar 

  28. Ortiz MV, Fernandez-Ledon S, Ramaswamy K, Forlenza CJ, Shukla NN, Kobos R, et al. Maintenance chemotherapy to reduce the risk of a metachronous Wilms Tumour in children with bilateral nephroblastomatosis. Pediatr Blood Cancer. 2019;66:e27500.

    Article  PubMed  Google Scholar 

  29. Jagt CT, Zuckermann M, Ten Kate F, Taminiau JA, Dijkgraaf MG, Heij H, et al. Veno-occlusive disease as a complication of preoperative chemotherapy for Wilms Tumour: A clinico-pathological analysis. Pediatr Blood Cancer. 2009;53:1211–5.

    Article  PubMed  Google Scholar 

  30. Vanden Berg RN, Bierman EN, Noord MV, Rice HE, Routh JC. Nephron-sparing surgery for Wilms Tumour: A systematic review. Urol Oncol. 2016;34:24–32.

    Article  PubMed  Google Scholar 

  31. Fuchs J, Schunn MC, Schäfer JF, Ebinger M, Graf N, Furtwängler R, et al. Redo nephron-sparing surgery in stage V pediatric renal Tumours - A report from the SIOP/GPOH study group for renal Tumours. Eur J Surg Oncol. 2024;50:107265. Jan

    Article  PubMed  Google Scholar 

  32. Godzinski J, Graf N, Audry G. Current concepts in surgery for Wilms Tumour-the risk and function-adapted strategy. Eur J Pediatr Surg. 2014;24:457–60.

    Article  PubMed  Google Scholar 

  33. Breslow NE, Collins AJ, Ritchey ML, Grigoriev YA, Peterson SM, Green DM. End stage renal disease in patients with Wilms Tumour: Results from the National Wilms Tumour Study Group and the United States Renal Data System. J Urol. 2005;174:1972–5.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Aronson DC, Slaar A, Heinen RC, de Kraker J, Heij HA. Long-term outcome of bilateral Wilms Tumours (BWT). Pediatr Blood Cancer. 2011;56:1110–3.

    Article  PubMed  Google Scholar 

  35. Hubertus J, Günther B, Becker K, Graf N, Furtwängler R, Ferrari R, et al. Development of hypertension is less frequent after bilateral nephron sparing surgery for bilateral Wilms Tumour in a long-term survey. J Urol. 2015;193:262–6.

    Article  PubMed  Google Scholar 

  36. Kieran K, Williams MA, Dome JS, McGregor LM, Krasin MJ, Davidoff AM. Margin status and Tumour recurrence after nephron-sparing surgery for bilateral Wilms Tumour. J Pediatr Surg. 2013;48:1481–5.

    Article  PubMed  Google Scholar 

  37. Spiegl HR, Murphy AJ, Yanishevski D, Brennan RC, Li C, Lu Z, et al. Complications following Nephron-sparing surgery for Wilms tumour. J Pediatr Surg. 2020;55:126–9.

    Article  PubMed  Google Scholar 

  38. Beckwith JB, Kiviat NB, Bonadio JF. Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms’ Tumour. J Pediatr Surg. 2020;55:126–9.

    Google Scholar 

  39. Cozzi F, Schiavetti A, Cozzi DA, Morini F, Uccini S, Pierani P, et al. Conservative management of hyperplastic and multicentric nephroblastomatosis. J Urol. 2004;172:1069–70.

    Article  Google Scholar 

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Acknowledgements

We acknowledge the enormous efforts made by more than 1000 clinicians working at the 251 childhood cancer treatment centres from 26 countries who enroled and followed up with patients in this study, and the patients and their families for their participation. The SIOP Renal Tumours Study Group and all authors thank the members of the independent data monitoring committee: Max Coppes (British Columbia Cancer Agency, Canada), Otilia Dalesio (Netherlands Cancer Institute, Amsterdam), and Dietmar Schmidt (Mannheim, Germany). We also acknowledge Lucy Wilkie and Aidan McManus for editorial assistance with the journal style and formatting of the final draft.

Special Dedication We address a special memorial to Dr. Christophe Bergeron, dead in December 2023 who has initiated this work in the spectrum of BWT. He has played an important role in numerous initiatives and projects within SIOP and SFCE, including the SIOP Renal Tumour Study Group. He strongly contributed to our collaborative efforts in the field of paediatric renal tumours over many decades.

Funding

The SIOP WT 2001 study was funded by Cancer Research UK (grant C1188/A8687), the UK National Cancer Research Network and Children’s Cancer and Leukaemia Group (CCLG) (who supported the UK section), Société Française des Cancers de l’Enfant and Association Leon Berard Enfant Cancéreux and Enfant et Santé (who supported the French section), Gesellschaft fü r Pädiatrische Onkologie und Hämatologie and Deutsche Krebschilfe (grant 50-2709-Gr2, who supported the German section), Grupo Cooperativo Brasileiro para o Tratamento do Tumour de Wilms and Sociedade Brasileira de Oncologia Pediátrica (who supported the Brazilian section), the Spanish Society of Paediatric Haematology and Oncology and the Spanish Association Against Cancer (who supported the Spanish section) and SIOP-NL. K P-J is partly supported by the National Institute for Health Research Biomedical Research Centre Funding Scheme

Author information

Authors and Affiliations

  1. Department of Children and AYA Oncology, Centre Oscar Lambret, Lille, France

    Hélène Sudour-Bonnange

  2. Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands

    Harm van Tinteren, Cornelis P. van de Ven & Mary M. van den Heuvel-Eibrink

  3. Department of Pediatric Oncology, Hospital Universitario Virgen Del Rocio, Sevilla, Spain

    Gema L. Ramírez-Villar

  4. Department of Pediatric Surgery, Marciniak Hospital, Fieldorfa 2 and Department of Pediatric Traumatology and Emergency Medicine, Wroclaw Medical university, Wrocław, Poland

    Jan Godzinski

  5. Department of Pediatric Surgery, Hospital Trousseau, Paris, France

    Sabine Irtan & Georges Audry

  6. Theosor-Boveri Institute/Biocenter and Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Würzburg, Germany

    Manfred Gessler

  7. Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK

    Tanzina Chowdhury

  8. Department of Pediatric Surgery and Urology, University Hospital Tübingen, 72076, Tuebingen, Germany

    Joerg Fuchs

  9. Department of Pediatric Surgery, Leeds Teaching Hospital NHS Trust, Leeds, UK

    Mark Powis

  10. Department of Paediatric Surgery, St George’s University Hospital, London, UK

    Bruce Okoye

  11. Great Ormond Street Hospital for Children NHS Foundation Trust, London, WC1N 3JH, UK

    Naima Smeulders

  12. Department of Pathology, Sidra Medicine and weill Cornell Medicine- Qatar, Doha, Qatar

    Gordan M. Vujanic

  13. Department of Pediatric Hemato-Oncology, Hospital La Timone, Marseille, France

    Arnaud Verschuur

  14. Department of Pathology; Hospital Trousseau, Paris, France

    Aurore L’Herminé-Coulomb

  15. Pediatric Hematology and Oncology program, research Center, Instituto National de Cancer, Rio de Janeiro, Brazil

    Beatriz de Camargo

  16. Department of Pediatric Hematology and Oncology, Hospital Santa Casa Belo-Horizonte, Belo Horizonte, Brazil

    Joaquim Caetano de Aguirre Neto

  17. Sektion Pädiatrische Radiologie, Klinik für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Heidelberg, Heidelberg, Deutschland

    Jens Peter Schenk

  18. Division of Childhealth, Wilhelmina Children’s Hospital, Utrecht, the Netherlands

    Mary M. van den Heuvel-Eibrink

  19. Developmental Biology and Cancer Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK

    Katy Pritchard-Jones

  20. Saarland University, Homburg, Germany

    Norbert Graf & Rhoikos Furtwängler

  21. Department of Pediatric Oncology and Hematology, Centre Léon Berard, Lyon, France

    Christophe Bergeron

  22. Division of Pediatric Hematology and Oncology, Department of Pediatrics, Inselspital, University Bern, Bern, Switzerland

    Rhoikos Furtwängler

Authors
  1. Hélène Sudour-Bonnange
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  2. Harm van Tinteren
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  3. Gema L. Ramírez-Villar
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  4. Jan Godzinski
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  5. Sabine Irtan
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  6. Manfred Gessler
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  7. Tanzina Chowdhury
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  8. Georges Audry
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  9. Joerg Fuchs
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Contributions

Hélène Sudour-Bonnange: Conceptualisation, Investigation, Writing – Original Draft, Writing – Review & Editing., Harm van Tinteren: Methodology, Formal analysis, Writing – Review & Editing, Gema L Ramírez-Villar: Investigation, Resources, Writing – Review & Editing, Jan Godzinski: Investigation, Resources, Writing – Review & Editing, Sabine Irtan: Investigation, Resources, Writing – Review & Editing, Manfred Gessler: Investigation, Resources, Writing – Review & Editing, Tanzina Chowdhury: Investigation, Resources, Writing – Review & Editing, Georges Audry: Investigation, Resources, Writing – Review & Editing, Joerg Fuchs: Investigation, Resources, Writing – Review & Editing, Mark Powis: Investigation, Resources, Writing – Review & Editing, Cornelis P van de Ven: Investigation, Resources, Writing – Review & Editing, Bruce Okoye: Investigation, Resources, Writing – Review & Editing, Naima Smeulders: Investigation, Resources, Writing – Review & Editing, Gordan M Vujanic: Investigation, Resources, Writing – Review & Editing, Arnaud Verschuur: Investigation, Resources, Writing – Review & Editing, Aurore L’Herminé-Coulomb: Investigation, Resources, Writing – Review & Editing, Beatriz de Camargo: Investigation, Resources, Writing – Review & Editing, Joaquim Caetano de Aguirre Neto: Investigation, Resources, Writing – Review & Editing, Jens Peter Schenk: Investigation, Resources, Writing – Review & Editing, Mary M van den Heuvel-Eibrink: Investigation, Resources, Writing – Review & Editing, Kathy Pritchard-Jones: Investigation, Resources, Writing – Review & Editing, Norbert Graf: Investigation, Resources, Writing – Review & Editing, Christophe Bergeron: Conceptualisation, Investigation, and Rhoikos Furtwängler: Conceptualisation, Investigation, Writing – Review & Editing, Supervision.

Corresponding author

Correspondence to Hélène Sudour-Bonnange.

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Sudour-Bonnange, H., van Tinteren, H., Ramírez-Villar, G.L. et al. Characteristics and outcome of synchronous bilateral Wilms tumour in the SIOP WT 2001 Study: Report from the SIOP Renal Tumour Study Group (SIOP-RTSG). Br J Cancer 131, 972–981 (2024). https://doi.org/10.1038/s41416-024-02799-0

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