![](http://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41409-024-02396-y/MediaObjects/41409_2024_2396_Figa_HTML.png)
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
![](http://media.springernature.com/m312/springer-static/image/art%3A10.1038%2Fs41409-024-02396-y/MediaObjects/41409_2024_2396_Fig1_HTML.png)
Data availability
The original data may be available from the corresponding author upon reasonable request and with permission of the Japan Society for Transplantation and Cellular Therapy and Japanese Data Center for Hematopoietic Cell Transplantation.
References
Eapen M, Giralt SA, Horowitz MM, Klein JP, Wagner JE, Zhang M-J, et al. Second transplant for acute and chronic leukemia relapsing after first HLA-identical sibling transplant. Bone Marrow Transpl. 2004;34:721–7.
Christopeit M, Kuss O, Finke J, Bacher U, Beelen DW, Bornhäuser M, et al. Second allograft for hematologic relapse of acute leukemia after first allogeneic stem-cell transplantation from related and unrelated donors: the role of donor change. J Clin Oncol. 2013;31:3259–71.
Bejanyan N, Weisdorf DJ, Logan BR, Wang HL, Devine SM, de Lima M, et al. Survival of patients with acute myeloid leukemia relapsing after allogeneic hematopoietic cell transplantation: a center for international blood and marrow transplant research study. Biol Blood Marrow Transpl. 2015;21:454–9.
Taga T, Murakami Y, Tabuchi K, Adachi S, Tomizawa D, Kojima Y, et al. Role of second transplantation for children with acute myeloid leukemia following posttransplantation relapse. Pediatr Blood Cancer. 2016;63:701–5.
Zuanelli Brambilla C, Lobaugh SM, Ruiz JD, Dahi PB, Goldberg AD, Young JW, et al. Relapse after allogeneic stem cell transplantation of acute myelogenous leukemia and myelodysplastic syndrome and the importance of second cellular therapy. Transpl Cell Ther. 2021;27:771 e1.
Yerushalmi Y, Shem-Tov N, Danylesko I, Canaani J, Avigdor A, Yerushalmi R, et al. Second hematopoietic stem cell transplantation as salvage therapy for relapsed acute myeloid leukemia/myelodysplastic syndromes after a first transplantation. Haematologica. 2023;108:1782–92.
Atsuta Y. Introduction of transplant registry unified management program 2 (TRUMP2): scripts for TRUMP data analyses, part I (variables other than HLA-related data). Int J Hematol. 2016;103:3–10.
Bacigalupo A, Ballen K, Rizzo D, Giralt S, Lazarus H, Ho V, et al. Defining the intensity of conditioning regimens: working definitions. Biol Blood Marrow Transpl. 2009;15:1628–33.
Yaniv I, Krauss AC, Beohou E, Dalissier A, Corbacioglu S, Zecca M, et al. Second Hematopoietic stem cell transplantation for post-transplantation relapsed acute leukemia in children: a retrospective EBMT-PDWP study. Biol Blood Marrow Transpl. 2018;24:1629–42.
Sharma A, Li Y, Huang S, Talleur AC, Suliman A, Qudeimat A, et al. Outcomes of pediatric patients who relapse after first HCT for acute leukemia or MDS. Bone Marrow Transpl. 2021;56:1866–75.
Orti G, Sanz J, Bermudez A, Caballero D, Martinez C, Sierra J, et al. Outcome of second allogeneic hematopoietic cell transplantation after relapse of myeloid malignancies following allogeneic hematopoietic cell transplantation: a retrospective cohort on behalf of the grupo espanol de trasplante hematopoyetico. Biol Blood Marrow Transpl. 2016;22:584–8.
Acknowledgements
We would like to thank all the participating patients and doctors involved in the Transplant Registry Unified Management Program in collaboration with the Japanese Data Center for Hematopoietic Cell Transplantation, Japan Society for Transplantation and Cellular Therapy, Japan Society for Pediatric Hematology and Oncology, Japan Marrow Donor Program, Cord Blood Banks and Japanese Red Cross Society.
Author information
Authors and Affiliations
Consortia
Contributions
HSak, TT, HI, AH, and YO designed the study, analyzed the data, and wrote the manuscript. HSan, MS, YK, KK, FI, NY, YC, KO, KW, AW, DH, and MN contributed to the registration. YH, KM, and KT are responsible for data management. All authors discussed and approved the manuscript.
Corresponding author
Ethics declarations
Competing interests
The authors declare that they have no competing interests. This study was partially supported by a grant from the National Centre for Child Health and Development (2024B-15).
Additional information
Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary information
Rights and permissions
About this article
Cite this article
Sakaguchi, H., Taga, T., Ishida, H. et al. Salvage hematopoietic cell transplantation for children with acute myeloid leukemia relapsed after first transplantation: a Japanese national registry study. Bone Marrow Transplant (2024). https://doi.org/10.1038/s41409-024-02396-y
Received:
Revised:
Accepted:
Published:
DOI: https://doi.org/10.1038/s41409-024-02396-y