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Cells with cFos and 53BP1 immunoreactivity in the CA1 region of the hippocampus from a young female apolipoprotein E4 (apoE) targeted replacement mouse 1.5 h after fear conditioning

Molecular Psychiatry volume 28, page 3145 (2023)Cite this article

Representative images of cFos and 53BP1 immunoreactive cells in the CA1 region of the hippocampus from a young female apolipoprotein E4 (apoE) targeted replacement mouse 1.5 h after fear conditioning. Images were taken of young (3 month) and middle-aged (12 months) male and female mice that were never exposed to fear conditioning (behaviorally naïve), euthanized 1.5 h after fear conditioning, or euthanized 24 h after fear conditioning. Young, female mice had a transient increase in cFos immunoreactive cells which was absent in young male mice. Middle-aged E2 female and male mice maintained the transient increase in cFos immunoreactive cells, while middle-aged E3 and E4 mice did not. There were no differences detected in 53BP1 immunoreactive cells. DAPI counterstain was used to identify nuclei. White arrows indicate cFos immunoreactive cells, yellow arrows indicate cells that contain 53BP1 foci. The bottom images are enlargements of the white boxes. Images were taken in the OHSU Microscopy Core Facilities.

For more information, please refer to the article by Boutros et al., in this issue.

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Author notes

  1. Sydney Weber Boutros

    Present address: Department of Psychological Sciences, Boise State University, 2133 W Cesar Chavez Ln, Boise, ID, 83725, USA

Authors and Affiliations

  1. Department of Behavioral Neuroscience, OHSU, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA

    Sydney Weber Boutros, Benjamin Zimmerman, Sydney C. Nagy & Jacob Raber

  2. Advanced Imaging Research Center, OHSU, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA

    Benjamin Zimmerman

  3. Helfgott Research Institute, NUNM, 2201 SW First Avenue, Portland, OR, 97201, USA

    Benjamin Zimmerman

  4. Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 N, Matthews Avenue, Urbana, IL, 61801, USA

    Benjamin Zimmerman

  5. Department of Neurology, OHSU, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA

    Vivek K. Unni & Jacob Raber

  6. Jungers Center for Neurosciences Research, OHSU, and OHSU Parkinson Center, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA

    Vivek K. Unni

  7. Departments of Psychiatry and Radiation Medicine, OHSU, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA

    Jacob Raber

  8. Division of Neuroscience, ONPRC, 505 NW 185th Ave, Beaverton, OR, 97006, USA

    Jacob Raber

Authors
  1. Sydney Weber Boutros
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  2. Benjamin Zimmerman
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  3. Sydney C. Nagy
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  4. Vivek K. Unni
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  5. Jacob Raber
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Corresponding author

Correspondence to Jacob Raber.

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Boutros, S.W., Zimmerman, B., Nagy, S.C. et al. Cells with cFos and 53BP1 immunoreactivity in the CA1 region of the hippocampus from a young female apolipoprotein E4 (apoE) targeted replacement mouse 1.5 h after fear conditioning. Mol Psychiatry 28, 3145 (2023). https://doi.org/10.1038/s41380-023-02301-x

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