Abstract
Background
Few studies have assessed associations between allergic diseases and antibacterial agents in Taiwanese children.
Objective
This study aimed to investigate the association of triclosan (TCS) exposure with allergic diseases among preschoolers, disease-specific IgE titers, and a child’s sex.
Methods
Pediatric data were obtained from the Childhood Environment and Allergic Diseases Study (CEAS; 2010) cohort, and their urine and blood samples were used to analyze TCS and IgE concentrations (age 3 group). Three years later, clinical data were obtained again from the age 3 group (age 6 group). Correlations of TCS levels at ages 3 and 6 years with IgE levels and allergic diseases were evaluated.
Results
The TCS levels were higher at age 3 than at age 6 (geometric mean, 1.05 ng/ml vs 0.37 ng/ml). TCS levels were positively correlated with serum IgE levels at ages 3 and 6 years. Asthma and atopic dermatitis were significantly associated with TCS (adjusted OR 1.14, 95% confidence interval [CI] 1.01–1.29; OR 1.22, 95% CI 1.05–1.41). Sex-stratified analysis revealed that TCS levels were positively correlated with IgE levels among boys in the age 6 group and significantly associated with asthma, allergic rhinitis, and atopic dermatitis among boys.
Significance
TCS exposure is associated with IgE levels and a potentially high risk of pediatric atopic disorders.
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Acknowledgements
The authors are very thankful to the Editors and the anonymous reviewers for their constructive comments to improve the quality of this article. The authors also thank the CEAS study group (Mr. Han-Hsing Tsou for urine analysis and Professor Meilien Chen, our colleague, for data collection).This manuscript was edited by Wallace Academic Editing.
Funding
This study was supported by grants from theMinistry of Science and Technology (MOST 106-2314-B-192 -001 -MY3) and Taipei Hospital, Ministry of Health and Welfare in Taiwan.
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Conceptualization: M.-H.L., S.-Y.C.; methodology: I.-J.W., W.-C.H.; formal analysis: I.-J.W., T.-Y.L., K.-H.C.; data curation: I.-J.W., M.-H.L., K.-H.C. T.-Y.L.; writing—original draft preparation: M.-H.L., S.-Y.C., I.-J.W.; writing—review and editing: I.-J.W., M.-H.L., S.-Y.C.; supervision: I.-J.W., W.-C.H.
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Lin, MH., Chiu, SY., Ho, WC. et al. Effect of triclosan on the pathogenesis of allergic diseases among children. J Expo Sci Environ Epidemiol 32, 60–68 (2022). https://doi.org/10.1038/s41370-021-00304-w
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DOI: https://doi.org/10.1038/s41370-021-00304-w
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