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Pediatrics

Mode of delivery, type of labor, and measures of adiposity from childhood to teenage: Project Viva

International Journal of Obesity volume 45, pages 36–44 (2021)Cite this article

Subjects

Abstract

Background

Cesarean delivery has been linked with childhood obesity. Few studies have examined if this association is attenuated if there is labor prior to delivery. The objective of this current analysis was to examine the association of cesarean vs. vaginal delivery with measures of childhood adiposity, and whether the association differs by labor type (spontaneous, induced, or absent) preceding cesarean delivery.

Methods

We ascertained delivery mode and type of labor from medical records in 1443 mother–child dyads from Project Viva with adiposity measures from at least one follow-up visit (3369 total observations) in early childhood (median age 3.2 y), mid-childhood (median 7.7 y), or early teen (median 12.9 y). Child adiposity outcomes were CDC age- and sex-specific body mass index (BMI) z-scores, sum of subscapular and triceps skinfold thicknesses (SS + TR; mm), and waist circumference (cm). We used linear regression models with generalized estimating equation estimates and adjusted for maternal age, education, race/ethnicity, prepregnancy BMI, rate of gestational weight gain, and child sex and age at outcome.

Results

A total of 333 (23%) women delivered via cesarean, including 155 (11%) with spontaneous labor, 74 (5%) with induced labor, 99 (7%) with no labor, and 5 (<1%) with unknown labor status. Compared to vaginal-delivered children, cesarean-delivered children had higher BMI-z (0.15, 95% CI: 0.04, 0.26); and non-significantly higher waist circumference (0.50 cm, 95% CI: −0.34, 1.34) and SS + TR (0.47 mm, 95% CI: −0.52, 1.46). Cesarean deliveries that were preceded by spontaneous labor were not associated with childhood BMI-z (0.08, 95% CI: −0.07, 0.23), waist circumference (−0.12 cm, 95% CI: −1.09, 0.85), or SS + TR (−0.25 mm, 95% CI: −1.44, 0.93), as compared to vaginal deliveries.

Conclusion

Cesarean delivery was associated with higher childhood BMI-z, and although waist circumference and SS + TR trended in the same direction, these associations were not significant. Cesarean delivery preceded by spontaneous labor was not associated with adiposity outcomes.

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Acknowledgements

Funding Grants from the US National Institutes of Health (R01 HD034568, R01 HD093761, UH3 OD023286, P30 DK046200). NTM is supported by the National Heart, Lung, and Blood Institute grant (K01HL141589).

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Authors and Affiliations

  1. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

    Noel T. Mueller & Mingyu Zhang

  2. Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Noel T. Mueller & Mingyu Zhang

  3. Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA

    Sheryl L. Rifas-Shiman, Emily Oken & Marie-France Hivert

  4. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Emily Oken & Jorge Chavarro

  5. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA

    Jorge Chavarro

  6. Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA

    Marie-France Hivert

  7. Department of Medicine, Universite de Sherbrooke, Sherbrooke, QC, Canada

    Marie-France Hivert

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  1. Noel T. Mueller
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Correspondence to Noel T. Mueller.

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Mueller, N.T., Zhang, M., Rifas-Shiman, S.L. et al. Mode of delivery, type of labor, and measures of adiposity from childhood to teenage: Project Viva. Int J Obes 45, 36–44 (2021). https://doi.org/10.1038/s41366-020-00709-x

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