Abstract
Introduction: Severe anti-D hemolytic disease carries a high risk of fetal and neonatal rrtoribidity and mortality.
Objective: To present the results of management of neonates with Rh incompatibility treated in-utero with transfusions.
Material & Methods: A total of 30 neonates were studied. The level of hemoglobin and bilirubin at birth, the presence of hydrops fetalis, and the need for mechanical ventilation and correction of hematologic parameters were assessed.
Results: Hydrops fetalis was present in 8 cases (27%). Mean gestational age at delivery was 33.42 weeks, and mean birth weight was 2017±348 g. In 63% of the cases cord blood hematocrit was below 30%, and in 70% billirubin was higher than 4 mg%. Neonatal transfunsional therapy was required in 90% of the cases, and exchange-transfusion in 73% of them. Twenty-one babies underwent mechanical ventilation, and there were 6 neonatal deaths. Mean neonatal survival rate was 80%.
Conclusion: Successful treatment of neonates with severe Rh incompatibility and previous intrauterine transfusions depended on the degree of prematurity and asphyxia, on the fetal hemodynamic condition, and on the presence and severity of hydrops fetalis.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ferreiro, G., Sexer, H., Bonifacino, G. et al. MANAGEMENT OF NEONATES WITH Rh INCOMPATIBILITY AND PREVIOUS IN-UTERO TRANSFUSIONS. Pediatr Res 36, 826 (1994). https://doi.org/10.1203/00006450-199412000-00043
Issue Date:
DOI: https://doi.org/10.1203/00006450-199412000-00043