Abstract
Respiratory viruses are responsible for the majority of acute respiratory tract infections (ARI) in the newborn (NB). Recent evidence suggests a strong association between ARI and other pulmonary diseases and with incrased morbidity and mortality. The present study was designed to establish the relationship between respiratory viruses {Adenovirus - AV vs Respiratory Syncytial Virus - RSV) and severity of neonatal respiratory infectious disease. All NB with ARI and positive viral exam (AV and/or RSV) admitted to the Intensive Care Unit from 5/92 trhough 7/93 were prospectively studied. Viral antigens were detected by indirect Immunofluorescence. Serotype were determined by neutralization. Data were analyzed using relative frequencies. Odds Ratios was established using Cornfield's method.
None of the patients with RSV required a FiO2 >80%. Six NB with AV but none of the NB with RSV required more than 10 days in IMV. OR for IMV requirements was 4-fold greater for NB with AV compared to all other causes of ARI. These data show that NB with ARI due to AV had greater morbidity and higher risk for IMV. We conclude that in our population, ARI due to AV has greater severity when compared to other causes of respiratory infections.
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Rabasa, C., Fariña, D., Zambosco, G. et al. ACUTE VIRAL RESPIRATORY INFECTIONS IN THE NEWBORN. Pediatr Res 36, 824 (1994). https://doi.org/10.1203/00006450-199412000-00034
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DOI: https://doi.org/10.1203/00006450-199412000-00034