Abstract
The Vitamin D deficiency enhanced the risk of rickets in children. Previous studies in Ushuaia <55°S) showed that the 47% of infant population have diminish levels of 25 hyroxy-Vitamin D <25(OH)D) (8 ng/ml) at the end of winter, being normal at end of summer. To prevent the vitamin D deficiency a single dose of 150.000 IU of Vitamin-D2 was given to a group of 79 children from Ushuaia with age 8.6 ± 1.4 years (X ± SD). Serum levels of calcium, phosphorous, alkaline phosphatase, 25(OH)D, Parathyroid Hormone (PTH) and the ratio of urine calcium/urine creatinine in a 2 hs. urine sample (UCa/UCreat) was measured at basal, 6 weeks and 5 months (end of winter) after an oral Vitamin D2 dose. The results are as follows:
After the 150.000 IU of Vit D2 administration the serum 25(OH)D levels at the end of winter were similar to those at the begining of autumn, but significantly higher from those obtained in a previous study without Vit D (9.8±3.8 ng/ml) (p<0.001). PTH levels were higher at the end of winter, but this increment was lower than without Vit D. Both, serum calcium levels and the ration UCa/UCreat were lower at 5 months after dose. Neither hypercalcemia nor hypercalciuria were observed. Conclusion: A single dose of 150.000 IU of Vit D maintained appropriate levels of 250 HD without hypercalcemia nor hypercalciuria.
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Oliveri, M., Cassinelli, H., Ayala, M. et al. PREVENTION OF VITAMIN D DEFICIENCY IN USHUAIA. Pediatr Res 36, 823 (1994). https://doi.org/10.1203/00006450-199412000-00028
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DOI: https://doi.org/10.1203/00006450-199412000-00028