Abstract
ABSTRACT: Infection with human immunodeficiency virus (HIV) causes a progressive immunodeficiency, often manifested in adults by the development of infections with relatively rare, opportunistic organisms. However, in HIV-infected children, recurrent serious infections with common encapsulated bacteria, as well as recurrent minor bacterial and viral infections, may be early and frequent manifestations of HIV disease. The use of i.v. immune globulin (IVIG) has been shown to prevent infections in patients with primary immunodeficiency and in uncontrolled studies of HIV-infected children. This article reviews the problem of and immunologic predisposition for recurrent infections in pediatric HIV infection and reports on the use of IVIG for prophylaxis. Updated analysis from the National Institute of Child Health and Human Development IVIG Clinical Trial, a multicenter, double-blind, placebo-controlled trial of the safety and efficacy of IVIG for the prevention of infections in children with symptomatic HIV infection, is presented. Between March 1988 and January 1991, 376 children with clinical or immunologic evidence of HIV disease who were randomized to receive IVIG or albumin placebo were enrolled in this trial. In children with an entry CD4+ count of 200/mm3 or higher, IVIG significantly increased the time free from serious bacterial infections and significantly decreased the rates of minor bacterial infections and viral infections. (Pediatr Res 33 (Suppl): S80-S89, 1993)
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mofenson, L., Moye, J. Intravenous Immune Globulin for the Prevention of Infections in Children with Symptomatic Human Immunodeficiency Virus Infection. Pediatr Res 33 (Suppl 1), S80–S89 (1993). https://doi.org/10.1203/00006450-199333011-00015
Issue Date:
DOI: https://doi.org/10.1203/00006450-199333011-00015
This article is cited by
-
Impact of Immunoglobulin Therapy in Pediatric Disease: a Review of Immune Mechanisms
Clinical Reviews in Allergy & Immunology (2016)
-
The role of polyclonal intravenous immunoglobulin in treating HIV-infected children with severe bacterial infections: A retrospective cohort study
BMC Infectious Diseases (2008)
-
Prevention of Infections in Children with Human Immunodeficiency Virus Infection
Clinical Immunotherapeutics (1994)