Abstract
In attempt to further differentiate cytochemically and inmunologically defined subtypes of ALL AcP isoenzyme patterns of various cell extracts were investigated by isoeleotric focusing in gels.
Isoenzyme patterns of T-ALL blasts were found to be identical to that of normal and fetal thymus cells. Also one case of BURKITT lymphoma, investigated so far, did not show any significant difference of AcP isoenzymes to T-ALL. The so called Non T- Non B-ALL however turned out to be a heterogenous group with different cytochemical and isoenzymic AcP patterns: cytochemically undifferentiated cells either contained only one single band of AcP or no AcP waa detectable. In cases of cytochemically weak and insignificant positive AoP reaction several AcP isoenzymes could be demonstrated by isoelectric focusing but fewer than in T-ALL.
Subgrouping of Non T- Non B-ALL seema to be posaible by the determination of enzyme markers.
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Gaedicke, G., Arndt, R. & Landbeck, G. ACID PHOSPHATASE (AcP) ISOENZYMES IS CHILDHOOD ALL. Pediatr Res 12, 66 (1978). https://doi.org/10.1203/00006450-197801000-00037
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DOI: https://doi.org/10.1203/00006450-197801000-00037