Abstract
Malignant lymphoma with leukemic conversion is characterized by a rapid tumor progression and poor prognosis. In acute lymphocytic leukemia however the outlook has improved markedly in the last years. Many children exhibit complete remission for a long time and cure is even possible. In order to differentiate between this two diseases and to treat patients separately, we analyzed the clinical data of 8 children, aged 2 to 12 years, who entered the children's hospital of St. Gallen in the last year. Based on clinical findings and with the aid of a biopsy (EM), cytochemical and immunological studies, we interpreted 4 patients as stage IV non Hodgkin lymphoma with leukemic transformation and 4 patients as acute lymphocytic leukemia.
Of the 4 patients with malignant lymphoma, diffuse lymphoblastic, the new entity “convoluted type” was seen in 2 patients. One was a 3 months old baby with probably congenital malignant lymphoma.
The distinction between acute lymphocytic leukemia and non Hodgkin lymphoma with bone marrow involvement is made on clinical criterias. These criterias are discussed.
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Feldges, A., Westerhausen, H. & Schmid, U. DISTINCTION BETWEEN ACUTE LYMPHOCYTIC LEUKEMIA AND MALIGNANT LYMPHOMA WITH LEUKEMIC TRANSFORMATION. Pediatr Res 12, 65 (1978). https://doi.org/10.1203/00006450-197801000-00032
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DOI: https://doi.org/10.1203/00006450-197801000-00032