The tumor suppressor protein 53BP1 decorates DNA damage sites and is instrumental for nonhomologous end joining. Evidence that 53BP1 facilitates synapsis of DNA ends by modulating chromatin dynamics reveals a hitherto unanticipated strategy for joining distant ends.
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Huen, M., Chen, J. When loose ends finally meet. Nat Struct Mol Biol 15, 1241–1242 (2008). https://doi.org/10.1038/nsmb1208-1241
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DOI: https://doi.org/10.1038/nsmb1208-1241
