The structure of the ligand-binding domains of Vibrio harveyi LuxPQ bound to Autoinducer-2 reveals a dramatic asymmetry in quaternary structure induced by ligand binding. Structures of receptor-sensing domains in both occupied and unoccupied states provide a foundation for postulating mechanisms of transmembrane signaling.
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Stock, A. Transmembrane signaling by asymmetry. Nat Struct Mol Biol 13, 861–862 (2006). https://doi.org/10.1038/nsmb1006-862
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DOI: https://doi.org/10.1038/nsmb1006-862