Eukaryotic transcriptomes are considerably larger than estimated from simple gene counts. However, much of this 'excess' RNA is immediately cleared from cells. Two recent studies reveal that so-called cryptic unstable transcripts constitutively transcribed from the yeast genome are rapidly eliminated in a process that couples transcription termination to RNA degradation.
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Ebbe Sloth Andersen
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Lykke-Andersen, S., Jensen, T. CUT it out: silencing of noise in the transcriptome. Nat Struct Mol Biol 13, 860–861 (2006). https://doi.org/10.1038/nsmb1006-860
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DOI: https://doi.org/10.1038/nsmb1006-860
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