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Dueling RNA-binding proteins promote translational activation

Nature Structural & Molecular Biology volume 24, pages 609–610 (2017)Cite this article

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Meiotic progression is controlled by cytoplasmic polyadenylation and translational activation of masked, maternal mRNAs. RNA-binding-protein interactions with adjacent cis elements cause local conformational changes to the mRNAs that determine the extent and timing of their activation.

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Figure 1: Stem cell divisions in sensory-organ development in wild-type and musashi (msi) mutant Drosophila melanogaster.
Figure 2: The juxtaposition of RNA motifs enables cooperative regulation by CPEB1 and Msi1.

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  1. the Department of Biology at McGill University, Montreal, Quebec, Canada

    Paul Lasko

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  1. Paul Lasko
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Correspondence to Paul Lasko.

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Lasko, P. Dueling RNA-binding proteins promote translational activation. Nat Struct Mol Biol 24, 609–610 (2017). https://doi.org/10.1038/nsmb.3445

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