The mechanisms guiding the substrate specificity of kinases are still poorly understood. Two recent reports provide further insights into how the epidermal growth factor receptor (EGFR) tyrosine kinase recognizes targets by identifying a new consensus motif that requires a Src-mediated priming phosphorylation.
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References
Dephoure, N., Gould, K.L., Gygi, S.P. & Kellogg, D.R. Mol. Biol. Cell 24, 535–542 (2013).
Cohen, P. Trends Biochem. Sci. 25, 596–601 (2000).
Park, E. et al. Nat. Struct. Mol. Biol. 22, 703–711 (2015).
Begley, M.J. et al. Nat. Struct. Mol. Biol. 22, 983–990 (2015).
Voldborg, B.R., Damstrup, L., Spang-Thomsen, M. & Poulsen, H.S. Ann. Oncol. 8, 1197–1206 (1997).
Normanno, N. et al. Gene 366, 2–16 (2006).
Tanoue, T., Adachi, M., Moriguchi, T. & Nishida, E. Nat. Cell Biol. 2, 110–116 (2000).
Schulman, B.A., Lindstrom, D.L. & Harlow, E. Proc. Natl. Acad. Sci. USA 95, 10453–10458 (1998).
Kõivomägi, M. et al. Nat. Struct. Mol. Biol. 20, 1415–1424 (2013).
Levinson, N.M., Seeliger, M.A., Cole, P.A. & Kuriyan, J. Cell 134, 124–134 (2008).
Fan, Y.X., Wong, L. & Johnson, G.R. Biochem. J. 392, 417–423 (2005).
Chang, X. et al. PLoS One 8, e68966 (2013).
Zhang, X. et al. Nature 450, 741–744 (2007).
Jura, N. et al. Cell 137, 1293–1307 (2009).
Biscardi, J.S. et al. J. Biol. Chem. 274, 8335–8343 (1999).
Tice, D.A., Biscardi, J.S., Nickles, A.L. & Parsons, S.J. Proc. Natl. Acad. Sci. USA 96, 1415–1420 (1999).
Kloth, M.T. et al. J. Biol. Chem. 278, 1671–1679 (2003).
Wheeler, D.L. et al. Cancer Biol. Ther. 8, 696–703 (2009).
Creixell, P. et al. Cell 163, 187–201 (2015).
Kovacs, E. et al. Mol. Cell. Biol. 35, 3083–3102 (2015).
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Michael, N., Jura, N. Src defines a new pool of EGFR substrates. Nat Struct Mol Biol 22, 945–947 (2015). https://doi.org/10.1038/nsmb.3137
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DOI: https://doi.org/10.1038/nsmb.3137