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Ribosomal 60S-subunit production: the final scene

Nature Structural & Molecular Biology volume 22, pages 837–838 (2015)Cite this article

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Newly synthesized 60S ribosomal subunits are licensed for translation through the release of the antiassociation factor eIF6. A new study shows by cryo–electron microscopy how eIF6 eviction results from a long-range allosteric cascade that involves SBDS, the protein mutated in Shwachman-Diamond syndrome.

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Figure 1: Model of eIF6 release by SBDS and EFL1 from the pre-60S particle.

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Authors and Affiliations

  1. Célia Plisson-Chastang, Natacha Larburu and Pierre-Emmanuel Gleizes are at the Université de Toulouse, Université Paul Sabatier, Laboratoire de Biologie Moléculaire Eucaryote, Toulouse, France, and CNRS, UMR 5099, Toulouse, France.,

    Célia Plisson-Chastang, Natacha Larburu & Pierre-Emmanuel Gleizes

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  1. Célia Plisson-Chastang
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  2. Natacha Larburu
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  3. Pierre-Emmanuel Gleizes
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Correspondence to Pierre-Emmanuel Gleizes.

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Plisson-Chastang, C., Larburu, N. & Gleizes, PE. Ribosomal 60S-subunit production: the final scene. Nat Struct Mol Biol 22, 837–838 (2015). https://doi.org/10.1038/nsmb.3121

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