The cellular 'alarmone' molecule ZTP accumulates when a critical cellular metabolic pathway is starved for substrate. The high-resolution structure of ZTP bound to its RNA-based sensor reveals unexpected strategies used by RNA to specifically recognize small-molecule ligands within the complex cellular mixture.
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Ruehle, M., Kieft, J. Molecular prejudice: RNA discrimination against purines allows response to a cellular alarm. Nat Struct Mol Biol 22, 754–756 (2015). https://doi.org/10.1038/nsmb.3095
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DOI: https://doi.org/10.1038/nsmb.3095