Two studies using chromosome conformation capture (3C) analyses in the Gram-positive bacterium Bacillus subtilis have revealed a global pattern of chromosome organization that originates from loading sites of the Smc–ScpAB complex. Loading Smc–ScpAB at a single genomic location is sufficient to promote genome-wide folding of DNA into a well-defined structure.
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Bürmann, F., Gruber, S. SMC condensin: promoting cohesion of replicon arms. Nat Struct Mol Biol 22, 653–655 (2015). https://doi.org/10.1038/nsmb.3082
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DOI: https://doi.org/10.1038/nsmb.3082
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