Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Meeting Report
  • Published:

The Hsp90 ensemble: coordinated Hsp90–cochaperone complexes regulate diverse cellular processes

Nature Structural & Molecular Biology volume 21, pages 1017–1021 (2014)Cite this article

Subjects

The Seventh International Conference on the Hsp90 Chaperone Machine took place in October 2014, in Seeon, Germany. The program highlighted recent findings in a variety of areas, including structures of heat-shock protein 90 (Hsp90)–client protein complexes, coordination of Hsp90 with cochaperones, new cellular and physiological roles for Hsp90 and therapeutic targeting of the Hsp90 ensemble for the treatment of disease and prevention of infection.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Modulation of cellular functions by influencing the Hsp90 ensemble.

References

  1. Soranno, A. et al. Proc. Natl. Acad. Sci. USA 111, 4874–4879 (2014).

    Article  CAS  Google Scholar 

  2. Kellner, R. et al. Proc. Natl. Acad. Sci. USA 111, 13355–13360 (2014).

    Article  CAS  Google Scholar 

  3. Lavery, L.A. et al. Mol. Cell 53, 330–343 (2014).

    Article  CAS  Google Scholar 

  4. Kirschke, E., Goswami, D., Southworth, D., Griffin, P.R. & Agard, D.A. Cell 157, 1685–1697 (2014).

    Article  CAS  Google Scholar 

  5. Pal, M. et al. Structure 22, 805–818 (2014).

    Article  CAS  Google Scholar 

  6. Ratzke, C., Hellenkamp, B. & Hugel, T. Nat. Commun. 5, 4192 (2014).

    Article  CAS  Google Scholar 

  7. Graf, G., Lee, C.-T., Meier-Andrejszki, L.E., Nguyen, M.T.N. & Mayer, M.P. Front. Mol. Biosci. 1, 4 (2014).

    Article  Google Scholar 

  8. Schweiger, R., Muller, N.C., Schmitt, M.J., Soll, J. & Schwenkert, S. J. Cell Sci. 125, 5196–5207 (2012).

    Article  CAS  Google Scholar 

  9. Willmer, T., Contu, L., Blatch, G.L. & Edkins, A.L. Cancer Lett. 328, 252–260 (2013).

    Article  CAS  Google Scholar 

  10. Soares, I.N. et al. Mol. Cell. Proteomics 12, 3253–3270 (2013).

    Article  CAS  Google Scholar 

  11. Ghosh, A., Stasch, J.P., Papapetropoulos, A. & Stuehr, D.J. J. Biol. Chem. 289, 15259–15271 (2014).

    Article  CAS  Google Scholar 

  12. Lorenz, O.R. et al. Mol. Cell 53, 941–953 (2014).

    Article  CAS  Google Scholar 

  13. Frumkin, A. et al. Front. Mol. Biosci. 1, 21 (2014).

    Article  Google Scholar 

  14. Mishra, P. & Bolon, D.N. Mol. Cell 53, 344–350 (2014).

    Article  CAS  Google Scholar 

  15. Nakamoto, H. et al. J. Biol. Chem. 289, 6110–6119 (2014).

    Article  CAS  Google Scholar 

  16. Seidler, P.M. et al. J. Mol. Biol. 426, 3590–3605 (2014).

    Article  CAS  Google Scholar 

  17. Gillan, V. & Devaney, E. Parasitology 141, 1203–1215 (2014).

    Article  CAS  Google Scholar 

  18. Wang, T., Bisson, W.H., Maser, P., Scapozza, L. & Picard, D. J. Med. Chem. 57, 2524–2535 (2014).

    Article  CAS  Google Scholar 

  19. Kaiser, E. et al. Infect. Immun. 79, 3913–3921 (2011).

    Article  CAS  Google Scholar 

  20. Wang, X. et al. Proc. Natl. Acad. Sci. USA 106, 21288–21293 (2009).

    Article  CAS  Google Scholar 

  21. Lu, X.A. et al. Biochem. J. 457, 171–183 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Serena Schwenkert is at the Department Biology I, Plant Sciences, Ludwig-Maximilians-Universität München, Planegg-Martinsried, Germany.,

    Serena Schwenkert

  2. Thorsten Hugel is at the Institute of Physical Chemistry, University of Freiburg, Freiburg, Germany.,

    Thorsten Hugel

  3. Marc B. Cox is at the Border Biomedical Research Center and the Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas, USA.,

    Marc B Cox

Authors
  1. Serena Schwenkert
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thorsten Hugel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Marc B Cox
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Serena Schwenkert, Thorsten Hugel or Marc B Cox.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Schwenkert, S., Hugel, T. & Cox, M. The Hsp90 ensemble: coordinated Hsp90–cochaperone complexes regulate diverse cellular processes. Nat Struct Mol Biol 21, 1017–1021 (2014). https://doi.org/10.1038/nsmb.2927

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb.2927

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing