The fate of an mRNA is regulated by internal base modifications that generate the modified nucleotides N6-methyladenosine, 5-methylcytosine and inosine. Three new studies show that yeast and human mRNAs also contain pseudouridine residues and that pseudouridylation is induced in various stress states, hinting at a new pathway for post-transcriptional control of mRNA.
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Jaffrey, S. An expanding universe of mRNA modifications. Nat Struct Mol Biol 21, 945–946 (2014). https://doi.org/10.1038/nsmb.2911
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DOI: https://doi.org/10.1038/nsmb.2911