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PrimPol breaks replication barriers

Nature Structural & Molecular Biology volume 20, pages 1348–1350 (2013)Cite this article

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Faithful bypass of replication forks encountering obstructive DNA lesions is essential to prevent fork collapse and cell death. PrimPol is a new human primase and translesion polymerase that is able to bypass fork-blocking UV-induced lesions and to restart replication by origin-independent repriming.

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Figure 1: Pathways to bypass replication lesions and avoid collapse of replication forks in human cells.

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Acknowledgements

I thank A. Doherty for discussions and the Swedish Cancer Society, the Swedish Children's Cancer Foundation, the Swedish Research Council, the Swedish Pain Relief Foundation, the European Research Council, the Wallenberg Foundation, and the Torsten and Ragnar Söderberg Foundations for funding my laboratory.

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  1. Division of Translational Medicine and Chemical Biology, Department of Medical Biochemistry and Biophysics, Thomas Helleday is at the Science for Life Laboratory, Karolinska Institutet, Stockholm, Sweden.,

    Thomas Helleday

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  1. Thomas Helleday
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Correspondence to Thomas Helleday.

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The author declares no competing financial interests.

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Helleday, T. PrimPol breaks replication barriers. Nat Struct Mol Biol 20, 1348–1350 (2013). https://doi.org/10.1038/nsmb.2727

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