Sodium-coupled glutamate transporters regulate excitatory signaling in the brain. A new crystal structure shows how the substrate induces changes in the binding pocket of an archaeal transporter homolog, providing new insights into the mechanism of transport.
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References
Yernool, D., Boudker, O., Jin, Y. & Gouaux, E. Nature 431, 811–818 (2004).
Reyes, N., Ginter, C. & Boudker, O. Nature 462, 880–885 (2009).
Bendahan, A., Armon, A., Madani, N., Kavanaugh, M.P. & Kanner, B.I. J. Biol. Chem. 275, 37436–37442 (2000).
Brocke, L., Bendahan, A., Grunewald, M. & Kanner, B.I. J. Biol. Chem. 277, 3985–3992 (2002).
Jensen, S., Guskov, A., Rempel, S., Hänelt, I. & Slotboom, D.J. Nat. Struct. Mol. Biol. 20, 1224–1226 (2013).
Boudker, O., Ryan, R.M., Yernool, D., Shimamoto, K. & Gouaux, E. Nature 445, 387–393 (2007).
Groeneveld, M. & Slotboom, D.J. Biochemistry 49, 3511–3513 (2010).
Zerangue, N. & Kavanaugh, M.P. Nature 383, 634–637 (1996).
Levy, L.M., Warr, O. & Attwell, D. J. Neurosci. 18, 9620–9628 (1998).
Kanner, B.I. & Bendahan, A. Biochemistry 21, 6327–6330 (1982).
Kavanaugh, M.P., Bendahan, A., Zerangue, N., Zhang, Y. & Kanner, B.I. J. Biol. Chem. 272, 1703–1708 (1997).
Ryan, R.M., Compton, E.L. & Mindell, J.A. J. Biol. Chem. 284, 17540–17548 (2009).
Crisman, T.J., Qu, S., Kanner, B.I. & Forrest, L.R. Proc. Natl. Acad. Sci. USA 106, 20752–20757 (2009).
Zhang, Y., Bendahan, A., Zarbiv, R., Kavanaugh, M.P. & Kanner, B.I. Proc. Natl. Acad. Sci. USA 95, 751–755 (1998).
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Kanner, B. Substrate-induced rearrangements in glutamate-transporter homologs. Nat Struct Mol Biol 20, 1142–1144 (2013). https://doi.org/10.1038/nsmb.2685
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DOI: https://doi.org/10.1038/nsmb.2685
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