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Zooming in on eukaryotic translation initiation

Nature Structural & Molecular Biology volume 20, pages 1141–1142 (2013)Cite this article

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Translation initiation in eukaryotes is a complex and highly regulated process during which several initiation factors cooperate to recruit an initiator tRNA to the small ribosomal subunit, where the mRNA is scanned for an AUG start codon. Two recent reports provide new structural insights into this process and reveal key functions of initiation factors 1 (eIF1) and 1A (eIF1A) in start-codon selection in atomic detail.

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Figure 1: The binding of tRNAi and mRNA to the small (40S) ribosomal subunit and subsequent scanning of the mRNA for a start codon is assisted by initiation factors eIF1 and eIF1A.

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  1. Anders Liljas is at the Department of Biochemistry and Structural Biology, Lund University, Lund, Sweden.,

    Anders Liljas

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  1. Anders Liljas
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Correspondence to Anders Liljas.

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The author declares no competing financial interests.

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Liljas, A. Zooming in on eukaryotic translation initiation. Nat Struct Mol Biol 20, 1141–1142 (2013). https://doi.org/10.1038/nsmb.2684

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