Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Antibodies expose multiple weaknesses in the glycan shield of HIV

Nature Structural & Molecular Biology volume 20, pages 771–772 (2013)Cite this article

Subjects

A shield of glycans coats the viral-envelope proteins of HIV. Recent work shows how broadly neutralizing antibodies can recognize this shield despite structural variation in these 'self' carbohydrate structures.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Organization of the viral spike of HIV.
Figure 2: Schematic representations of the crystal structures of 2G12, PGT135 and PG16 in complex with their respective gp120 antigen.

References

  1. McCaffrey, R.A., Saunders, C., Hensel, M. & Stamatatos, L. J. Virol. 78, 3279–3295 (2004).

    Article  CAS  Google Scholar 

  2. Bonomelli, C. et al. PLoS ONE 6, e23521 (2011).

    Article  CAS  Google Scholar 

  3. Doores, K.J. et al. Proc. Natl. Acad. Sci. USA 107, 13800–13805 (2010).

    Article  CAS  Google Scholar 

  4. Kong, L. et al. Nat. Struct. Mol. Biol. 20, 796–803 (2013).

    Article  CAS  Google Scholar 

  5. Pancera, M. et al. Nat. Struct. Mol. Biol. 20, 804–813 (2013).

    Article  CAS  Google Scholar 

  6. Scanlan, C.N. et al. J. Virol. 76, 7306–7321 (2002).

    Article  CAS  Google Scholar 

  7. Sanders, R.W. et al. J. Virol. 76, 7293–7305 (2002).

    Article  CAS  Google Scholar 

  8. Calarese, D.A. et al. Science 300, 2065–2071 (2003).

    Article  CAS  Google Scholar 

  9. Walker, L.M. et al. PLoS Pathog. 6, e1001028 (2010).

    Article  Google Scholar 

  10. Pejchal, R. et al. Science 334, 1097–1103 (2011).

    Article  CAS  Google Scholar 

  11. McLellan, J.S. et al. Nature 480, 336–343 (2011).

    Article  CAS  Google Scholar 

  12. Mouquet, H. et al. Proc. Natl. Acad. Sci. USA 109, E3268–E3277 (2012).

    Article  CAS  Google Scholar 

  13. Wei, X. et al. Nature 422, 307–312 (2003).

    Article  CAS  Google Scholar 

  14. Doores, K.J. & Burton, D.R. J. Virol. 84, 10510–10521 (2010).

    Article  CAS  Google Scholar 

  15. Scanlan, C.N., Offer, J., Zitzmann, N. & Dwek, R.A. Nature 446, 1038–1045 (2007).

    Article  CAS  Google Scholar 

  16. Dunlop, D.C. et al. AIDS 22, 2214–2217 (2008).

    Article  CAS  Google Scholar 

  17. Dunlop, D.C. et al. Glycobiology 20, 812–823 (2010).

    Article  CAS  Google Scholar 

  18. Agrawal-Gamse, C. et al. J. Virol. 85, 470–480 (2011).

    Article  CAS  Google Scholar 

  19. Luallen, R.J. et al. Glycobiology 20, 280–286 (2010).

    Article  CAS  Google Scholar 

  20. White, T.A. et al. PLoS Pathog. 6, e1001249 (2010).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

T.A.B. is supported by a Sir Henry Wellcome Postdoctoral Fellowship. M.C. acknowledges the support of the International AIDS Vaccine Initiative Neutralizing Antibody Center and the Center for HIV/AIDS Vaccine Immunology and Immunogen Design.

Author information

Authors and Affiliations

  1. Department of Biochemistry, Max Crispin is at the Oxford Glycobiology Institute, University of Oxford, Oxford, UK.,

    Max Crispin

  2. Thomas A. Bowden is at the Division of Structural Biology, University of Oxford, Wellcome Trust Centre for Human Genetics, Oxford, UK.,

    Thomas A Bowden

Authors
  1. Max Crispin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thomas A Bowden
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Max Crispin.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Crispin, M., Bowden, T. Antibodies expose multiple weaknesses in the glycan shield of HIV. Nat Struct Mol Biol 20, 771–772 (2013). https://doi.org/10.1038/nsmb.2627

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nsmb.2627

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing