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EMI1, a three-in-one ubiquitylation inhibitor

Nature Structural & Molecular Biology volume 20, pages 773–774 (2013)Cite this article

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The anaphase-promoting complex/cyclosome (APC/C) is restricted by metazoan protein early mitotic inhibitor 1 (EMI1), a natural, potent inhibitor. New findings suggest that the multimodal inhibitory mechanisms of EMI1 control APC/C-dependent ubiquitylation.

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Figure 1: Model of EMI1-mediated APC/C inhibition.

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Authors and Affiliations

  1. Hiroyuki Yamano is at the Cell Cycle Control Group, University College London Cancer Institute, University College London, London, UK.,

    Hiroyuki Yamano

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  1. Hiroyuki Yamano
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Correspondence to Hiroyuki Yamano.

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The author declares no competing financial interests.

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Yamano, H. EMI1, a three-in-one ubiquitylation inhibitor. Nat Struct Mol Biol 20, 773–774 (2013). https://doi.org/10.1038/nsmb.2626

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