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SIMIBI twins in protein targeting and localization

Nature Structural & Molecular Biology volume 20, pages 776–780 (2013)Cite this article

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Abstract

Signal recognition particle, MinD and BioD (SIMIBI)-type nucleoside triphosphate–binding proteins are an ancient subfamily of nucleotide-binding proteins that serve in a wide range of cellular processes. Notably, this class comprises dimeric ATPases as well as GTPases (SIMIBI 'twins') and a subset of SIMIBI-type proteins, including SRP GTPases, MinD-type ATPases and the Get3 ATPase, is essential to protein targeting and localization. Here, we define common mechanistic principles and differences for these SIMIBI proteins.

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Figure 1: SIMIBI-class homo- and heterodimers.
Figure 2: Mechanistic model of SIMIBI twins.

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Acknowledgements

G.B. thanks the Peter & Traudl Engelhorn Foundation for support. I.S. is supported as an investigator of the Cluster of Excellence: CellNetworks and thanks the Deutsche Forschungsgemeinschaft for funding through the SFB638. The authors apologize that, owing to restrictions in the number of citations, it was not possible to give credit to all relevant publications.

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  1. Gert Bange

    Present address: Present address: LOEWE Zentrum für Synthetische Mikrobiologie, Philipps Universität Marburg, Marburg, Germany.,

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  1. Biochemie-Zentrum der Universität Heidelberg, INF328, Heidelberg, Germany

    Gert Bange & Irmgard Sinning

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Correspondence to Gert Bange or Irmgard Sinning.

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Bange, G., Sinning, I. SIMIBI twins in protein targeting and localization. Nat Struct Mol Biol 20, 776–780 (2013). https://doi.org/10.1038/nsmb.2605

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