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Solo or doppio: how many CENP-As make a centromeric nucleosome?

Nature Structural & Molecular Biology volume 20, pages 648–650 (2013)Cite this article

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Whether centromere-specific CENP-A–containing nucleosomes comprise one molecule each of CENP-A and histones H4, H2A and H2B (forming a tetramer or hemisome) or two molecules of all four histones (forming an octamer) has been controversial. Three new studies now address this controversy using complementary in vitro and in vivo approaches.

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Figure 1: Features of histone H3 and CENP-A nucleosome models.
Figure 2: Model for inheritance of human CENP-A octamers during the cell cycle.

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Authors and Affiliations

  1. Weiguo Zhang and Gary H. Karpen are at the Department of Genome Biology, Life Sciences Division, and the Department of Molecular and Cell Biology, Elaine M. Dunleavy, Lawrence Berkeley National Laboratory, Berkeley, California, USA, University of California Berkeley, Berkeley, California, USA.,

    Elaine M Dunleavy, Weiguo Zhang & Gary H Karpen

  2. Elaine M. Dunleavy is also at the Centre for Chromosome Biology, School of Natural Sciences, National University of Ireland, Galway, Ireland.,

    Elaine M Dunleavy

Authors
  1. Elaine M Dunleavy
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  2. Weiguo Zhang
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  3. Gary H Karpen
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Correspondence to Elaine M Dunleavy or Gary H Karpen.

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Dunleavy, E., Zhang, W. & Karpen, G. Solo or doppio: how many CENP-As make a centromeric nucleosome?. Nat Struct Mol Biol 20, 648–650 (2013). https://doi.org/10.1038/nsmb.2602

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