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RAF-isotype switching: from B to C through PDE

Nature Structural & Molecular Biology volume 18, pages 517–518 (2011)Cite this article

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A new study reveals that rewiring of MAPK signaling in cells expressing mutant RAS includes ERK-mediated BRAF inactivation and the concomitant activation of CRAF, partly through amplification by the phosphodiesterase 4 isoform.

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Figure 1: From BRAF to CRAF through PDE4.

Katie Vicari

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Authors and Affiliations

  1. Eric Lau and Ze'ev Ronai are in the Signal Transduction Program at the Sanford Burnham Medical Research Institute, La Jolla, California, USA.,

    Eric Lau & Ze'ev Ronai

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  1. Eric Lau
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  2. Ze'ev Ronai
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Correspondence to Ze'ev Ronai.

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The authors declare no competing financial interests.

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Lau, E., Ronai, Z. RAF-isotype switching: from B to C through PDE. Nat Struct Mol Biol 18, 517–518 (2011). https://doi.org/10.1038/nsmb.2063

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