Abstract
The linker histones, H1 and its variant forms, have been implicated in the formation of higher orders of chromatin structure and gene repression. Three recent manuscripts have reexamined the location of H1 within the nucleosome particle and its function in the regulation of transcription.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Identification of autoreactive B cells with labeled nucleosomes
Scientific Reports Open Access 04 April 2017
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Luger, K., Mäder, A.W., Richmond, R.K., Sargent, D.F. & Richmond, T.J. Nature 389, 251–260 (1997).
Owen-Hughes, T. & Workman, J.L. Crit. Rev. in Euk. Gene Expr. 4, 403–441 (1994).
Zhou, Y.-B., Gerchman, S.E., Ramakrishnan, V., Travers, A.A. & Muyldermans, S.V. Nature 395, 402–405 (1998).
Panetta, G., Buttinelli, M., Flaus, A., Richmond, T.J. & Rhodes, D. J. Mol. Biol. 282, 683–697 (1998).
Sera, T. & Wolffe, A.P. Mol. Cell. Biol. 18, 3668–3680 (1998).
Weintraub, H. Cell 42, 705–711 (1985).
Zlatanova, J. Trends Biochem. Sci. 15, 273–276 (1990).
Crane-Robinson, C. Trends Biochem. Sci. 22, 75–78 (1997).
Hartman, P.G., Chapman, G.E., Moss, T. & Bradbury, E.M. Eur. J. Biochem. 77, 45–51 (1977).
Cerf, C. et al. Biochemistry (1993).
Ramakrishnan, V., Finch, J.T., Graziano, V., Lee, P.L. & Sweet, R.M. Nature 362, 219–223 (1993).
Clark, K.L., Halay, E.D., Lai, E. & Burley, S.K. Nature 364, 412–420 (1993).
Thomas, J.O., Rees, C. & Finch, J.T. Nucleic Acid Res. 20, 187–194 (1992).
Krylov, D., Leuba, S.H., van Holde, K.E. & Zlatanova, J. Proc. Natl. Acad. Sci. USA 90, 5052–5056 (1993).
Varga-Weisz, P., van Holde, K.E. & Zlatanova, J. J. Biol. Chem. 268, 20699–20700 (1993).
Hamiche, A., Schultz, P., Ramakrishnan, V., Oudet, P. & Prunell, A. J. Mol. Biol. 257, 30–42 (1996).
Noll, M. & Kornberg, R.D. J. Mol. Biol. 109, 393–404 (1977).
Goytisolo, F.A. et al. EMBO J. 15, 3421–3429 (1996).
Simpson, R.T. Biochemistry 17, 5524–5531 (1978).
Hayes, J.J. & Wolffe, A.P. Proc. Natl. Acad. Sci. USA 90, 6415–6419 (1993).
Hayes, J.J., Pruss, D. & Wolffe, A.P. Proc. Natl. Acad. Sci. USA 91, 7817–7821 (1994).
An, W., van Holde, K.E. & Zlatanova, J. Nucleic Acid Res. 26, 4042–4047 (1998).
An, W., Leuba, S.H., van Holde, K.E. & Zlatanova, J. Proc. Natl. Acad. Sci. USA 95, 3396–3401 (1998).
Böhm, L. & Crane-Robinson, C. Bioscience Reports 4, 365–386 (1984).
Staynov, D.Z. & Crane-Robinson, C. EMBO J. 7, 3685–3691 (1988).
Lambert, S.F. et al. Biochem. and Biophys. Res. Comm. 179, 810–816 (1991).
Travers, A.A. & Muyldermans, S.V. J. Mol. Biol. 257, 486–491 (1996).
Pruss, D. et al. Science 274, 614–617 (1996).
Hayes, J.J. Biochemistry 35, 11931–11937 (1996).
Hayes, J.J., Kaplan, R., Ura, K., Pruss, D. & Wolffe, A.P. J. Biol. Chem. 271, 25817–25822 (1996).
Sirotkin, A.M. et al. Proc. Natl. Acad. Sci. USA 92, 6434–6438 (1995).
Shen, X., Yu, L., Weir, J.W. & Gorovsky, M.A. Cell 82, 47–56 (1995).
Shen, X. & Gorovsky, M.A. Cell 86, 475–483 (1996).
Patterton, H.G., Landel, C.C., Landsman, D., Peterson, C.L. & Simpson, R.T. J. Biol. Chem. 273, 7268–7276 (1998).
Juan, L.-J., Walter, P.P., Taylor, I.C.A., Kingston, R.E. & Workman, J.L. Cold Spring Harbor Symp. Quant. Biol. LVIII, 213–223 (1993).
Juan, L.-J., Utley, R.T., Adams, C.C., Vettese-Dadey, M. & Workman, J.L. EMBO J. 13(1994).
Juan, L.-J., Utley, R.T., Vignali, M., Bohm, L. & Workman, J. L. J. Biol. Chem. 272, 3635–3640 (1997).
Meersseman, G., Pennings, S. & Bradbury, E.M. J. Mol. Biol. 220, 89–100 (1991).
Schlissel, M.S. & Brown, D.D. Cell 37, 903–913 (1984).
Rhodes, D. EMBO J. 4, 3473–3482 (1985).
Flaus, A., Luger, K., Tan, S. & Richmond, T.J. Proc. Natl. Acad. Sci. USA 93, 1370–1375 (1996).
Howe, L. & Ausió, J. Mol. Cell. Biol. 18, 1156–1162 (1998).
Pruss, D. & Wolffe, A.P. Biochemistry 32(27), 6810–6814 (1993).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Vignali, M., Workman, J. Location and function of linker histones. Nat Struct Mol Biol 5, 1025–1028 (1998). https://doi.org/10.1038/4133
Issue Date:
DOI: https://doi.org/10.1038/4133
This article is cited by
-
Chromatin accessibility and the regulatory epigenome
Nature Reviews Genetics (2019)
-
Identification of autoreactive B cells with labeled nucleosomes
Scientific Reports (2017)
-
Deletions of IKZF1 and SPRED1 are associated with poor prognosis in a population-based series of pediatric B-cell precursor acute lymphoblastic leukemia diagnosed between 1992 and 2011
Leukemia (2014)
-
Regulation of stress-induced nuclear protein redistribution: a new function of Bax and Bak uncoupled from Bcl-xL
Cell Death & Differentiation (2010)
-
CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis
Nature Cell Biology (2009)