STAT5A/B represents a therapeutic target for advanced prostate cancer, but the mechanisms underlying increased Stat5 protein levels in prostate tumours are unclear. Now, Haddad et al. have demonstrated amplification at the STAT5A/B gene locus in a significant fraction of clinical prostate cancers, particularly those of high histological grades and in hormone-resistant distant metastases. Functional studies also showed that increased STAT5A/B copy number conferred a growth advantage in prostate cancer cells in vitro and in xenograft tumours in vivo.
ORIGINAL RESEARCH PAPER
Haddad, B. R. et al. STAT5A/B gene locus undergoes amplification during human prostate cancer progression. Am. J. Pathol. doi:10.1016/j.ajpath.2013.02.044
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First evidence of somatic STAT5A/B gene amplification. Nat Rev Urol 10, 369 (2013). https://doi.org/10.1038/nrurol.2013.125
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DOI: https://doi.org/10.1038/nrurol.2013.125