Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Parkinson disease

Unravelling the nonmotor mysteries of Parkinson disease

Nature Reviews Neurology volume 12, pages 10–11 (2016)Cite this article

Subjects

Parkinson disease (PD) is now regarded as a mixed motor, nonmotor and multiorgan disorder rather than a pure movement disorder. Nonmotor symptoms (NMS) have underpinned this conceptual change, and new criteria for clinical and prodromal diagnosis of PD, incorporating a range of NMS, have recently been published.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Proposed flowchart for research and diagnosis in prodromal Parkinson disease (PD).

References

  1. Parkinson, J. An Essay on the Shaking Palsy (Sherwood, Needly, and Jones, 1817).

    Google Scholar 

  2. Chaudhuri, K. R., Healy, D. G. & Schapira, A. H. Non-motor symptoms of Parkinson's disease: diagnosis and management. Lancet Neurol. 5, 235–245 (2006).

    Article  Google Scholar 

  3. Sauerbier, A., Jenner, P., Todorova, A. & Chaudhuri, K. R. Non motor subtypes and Parkinson's disease. Parkinsonism Relat. Disord. 22, S41–S46 (2016).

    Article  Google Scholar 

  4. Hughes, A. J., Daniel, S. E., Kilford, L. & Lees, A. J. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiatry 55, 181–184 (1992).

    Article  CAS  Google Scholar 

  5. Hawkes, C. H. The prodromal phase of sporadic Parkinson's disease: does it exist and if so how long is it? Mov. Disord. 23, 1799–1807 (2008).

    Article  Google Scholar 

  6. Noyce, A. J. et al. Meta-analysis of early nonmotor features and risk factors for Parkinson disease. Ann. Neurol. 72, 893–901 (2012).

    Article  CAS  Google Scholar 

  7. Postuma, R. B. et al. MDS clinical diagnostic criteria for Parkinson's disease. Mov. Disord. 30, 1591–1601 (2015).

    Article  Google Scholar 

  8. Berg, D. et al. MDS research criteria for prodromal Parkinson's disease. Mov. Disord. 30, 1600–1611 (2015).

    Article  Google Scholar 

  9. Gomperts, S. N. et al. Imaging amyloid deposition in Lewy body diseases. Neurology 71, 903–910 (2008).

    Article  CAS  Google Scholar 

  10. Schrag, A., Horsfall, L., Walters, K., Noyce, A. & Petersen, I. Prediagnostic presentations of Parkinson's disease in primary care: a case–control study. Lancet Neurol. 14, 57–64 (2015).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Maurice Wohl Clinical Neuroscience Institute, King's College London, 5 Cutcombe Road, London, SE5 9RT, UK

    K. Ray Chaudhuri & Anna Sauerbier

Authors
  1. K. Ray Chaudhuri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anna Sauerbier
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. Ray Chaudhuri.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

PowerPoint slides

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chaudhuri, K., Sauerbier, A. Unravelling the nonmotor mysteries of Parkinson disease. Nat Rev Neurol 12, 10–11 (2016). https://doi.org/10.1038/nrneurol.2015.236

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneurol.2015.236

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing