A new study elucidates how heterogenously located brain lesions can consistently lead to syndromes such as central poststroke pain. Investigators used structural MRI data from published and unpublished case reports of patients with hallucination disorders, central poststroke pain or aphasia, and mapped lesions onto a standard atlas. These maps were compared with open resting-state connectivity data, revealing how the lesions affected networks associated with patients' symptoms. This methodology might help to predict outcomes and prioritize care for patients after stroke or brain injury.