Temporal lobe epilepsy can be efficiently localized to the left or right hemispheres via analysis of 18F-FDG–PET data, according to a new report. Pustina and colleagues used stepwise linear regression to analyse PET, MRI and diffusion tensor imaging data from patients with epilepsy. PET scans were best for homing in on the seizure focus, and multimodal imaging did not yield further insight. When investigators applied a predictive model to new patients, the side of the seizure focus was identified with high accuracy.