Spinal cord injury induces an upregulation of glial-derived chondroitin sulphate proteoglycans (CSPGs), which suppress axonal regrowth. Now, a new study has shown that systemic delivery of a peptide mimetic of the protein tyrosinase phosphatase σ (PTPσ) receptor domain can restore serotonergic innervation and facilitate motor recovery in a rat model of spinal cord injury. The effect of PTPσ receptor modulation is thought to be mediated by reduced CSPG-mediated inhibition.
References
Lang, B. T. et al. Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury. Nature 10.1038/nature13974
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Modulation of the PTPσ receptor promotes recovery after spinal cord injury in rats. Nat Rev Neurol 11, 3 (2015). https://doi.org/10.1038/nrneurol.2014.242
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DOI: https://doi.org/10.1038/nrneurol.2014.242