The notion that the classic motor features of Parkinson disease (PD) are preceded by a prodrome has received renewed interest in the past decade. A recent study corroborates previous findings that smell loss and constipation are signifiers of nigral degeneration. But can we really predict who is going to get PD?
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References
Ross, G. W., Abbott, R. D., Petrovitch, H., Tanner, C. M. & White, L. R. Pre-motor features of Parkinson's disease: the Honolulu–Asia Aging Study experience. Parkinsonism Relat. Disord. 18 (Suppl. 1), S199–S202 (2012).
Jennings, D. et al. Imaging prodromal Parkinson disease: the Parkinson Associated Risk Syndrome Study. Neurology 83, 1739–1746 (2014).
Iranzo, A. et al. Neurodegenerative disorder risk in idiopathic REM sleep behavior disorder: study in 174 patients. PLoS ONE 9, e89741 (2014).
Silveira-Moriyama, L. & Lees, A. J. Up with the lark: a panoptic view of Parkinson disease. Neurology 77, 310–311 (2011).
Pare, P., Ferrazzi, S., Thompson, W. G., Irvine, E. J. & Rance, L. An epidemiological survey of constipation in Canada: definitions, rates, demographics, and predictors of health care seeking. Am. J. Gastroenterol. 96, 3130–3137 (2001).
Berg, D., Marek, K., Ross, G. W. & Poewe, W. Defining at-risk populations for Parkinson's disease: lessons from ongoing studies. Mov. Disord. 27, 656–665 (2012).
Ritz, B., Lee, P.-C., Lassen, C. F. & Arah, O. A. Parkinson disease and smoking revisited: ease of quitting is an early sign of the disease. Neurology 83, 1396–1402 (2014).
Noyce, A. J. et al. Meta-analysis of early nonmotor features and risk factors for Parkinson disease. Ann. Neurol. 72, 893–901 (2012).
Acknowledgements
L.S.-M. has received grants from the Reta Lila Howard Foundation, FAPESP, FAEPEX-UNICAMP, Parkinson's UK and CNPq-CAPES. A.J.L. has received grants from the PSP Association, the Weston Trust and the Reta Lila Howard Foundation. L.S.-M. would like to thank Professor Paulo A. Lotufo for helpful comments about constipation in women.
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L.S.-M. has received travel grants from Genus, Ipsen and Abbott. A.J.L. has consulted for Genus, and has served on advisory boards and received honoraria from Novartis, Teva, Meda, Boehringer Ingelheim, GSK, Ipsen, Lundbeck, Allergan, Orion, BIAL, Noscira and Roche.
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Silveira-Moriyama, L., Lees, A. How reliable are prodromal indicators of Parkinson disease?. Nat Rev Neurol 11, 5–6 (2015). https://doi.org/10.1038/nrneurol.2014.235
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DOI: https://doi.org/10.1038/nrneurol.2014.235