Finding a peripheral biomarker for early Alzheimer disease (AD) is a major challenge. A recent study has validated a plasma protein signature that is associated with mild cognitive impairment and AD, and could predict conversion; however, longitudinal cohort studies of presymptomatic individuals are needed to confirm the findings.
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Rembach, A. The search for a blood-based biomarker for Alzheimer disease. Nat Rev Neurol 10, 618–619 (2014). https://doi.org/10.1038/nrneurol.2014.182
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DOI: https://doi.org/10.1038/nrneurol.2014.182