A signature comprising 24 microRNAs has been linked to familial amyotrophic lateral sclerosis (ALS). Expression of these microRNAs was consistently reduced regardless of which ALS-linked gene patients carried. The downregulation was also observed in asymptomatic carriers of ALS-associated mutations up to 20 years before estimated disease onset. These microRNAs represent targets for novel ALS therapies, and might enable early intervention.
References
Freischmidt, A. et al. Serum microRNAs in patients with genetic amyotrophic lateral sclerosis and pre-manifest mutation carriers. Brain 10.1093/brain/awu249
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Familial amyotrophic lateral sclerosis is associated with a distinct serum microRNA profile. Nat Rev Neurol 10, 548 (2014). https://doi.org/10.1038/nrneurol.2014.174
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DOI: https://doi.org/10.1038/nrneurol.2014.174
